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TMIGD2 Is an Orchestrator and Therapeutic Target on Human Acute Myeloid Leukemia Stem Cells

[Nature Communications] Researchers showed that transmembrane and immunoglobulin domain containing 2 (TMIGD2), a recently discovered co-stimulatory immune receptor, was aberrantly expressed by human AML cells, and can be used to identify and enrich functional leukemia stem cells.

Modeling Bronchial Epithelial-Fibroblast Cross-Talk in Idiopathic Pulmonary Fibrosis (IPF) Using a Human-Derived In Vitro Air Liquid Interface (ALI) Culture

[Scientific Reports] Scientists investigate IPF dysregulated cross-talk, primary normal human bronchial epithelial cells and primary normal human lung fibroblasts or diseased human lung fibroblasts from IPF patients, were co-cultured in direct contact at the air–liquid interface.

YAP and TAZ Couple Osteoblast Precursor Mobilization to Angiogenesis and Mechanoregulation in Murine Bone Development

[Developmental Cell] Researchers showed that the mechanoresponsive transcriptional regulators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) spatially couple osteoblast precursor mobilization to angiogenesis, regulated vascular morphogenesis to control cartilage remodeling and mediate mechanoregulation of embryonic murine osteogenesis.

Type I Collagen and Fibromodulin Enhance the Tenogenic Phenotype of hASCs and Their Potential for Tendon Regeneration

[NPJ Regenerative Medicine] Researchers defined the effective extracellular matrix molecules capable of teno-lineage induction on human adipose-derived stem cells and tested their function for tendon engineering.

CD73-Positive Pediatric Urethral Mesenchymal Stem-Like Cell-Derived Small Extracellular Vesicles Stimulate Angiogenesis

[Regenerative Therapy] Investigators studied the pro-angiogenic effect of pediatric urethral mesenchymal stem-like cells-derived small extracellular vesicles and the underlying mechanisms.

Effects of ADSC-Derived Exosome LRRC75A-AS1 on Anti-inflammatory Function After SCI

[Applied Biochemistry And Biotechnology] Researchers examined how adipose-derived mesenchymal stem cell exosomes could be used to treat spinal cord injury. They analyzed differentially expressed mRNAs in spinal cord injury using bioinformatics data, gene expression profiles in inflammatory cell models, RT-qPCR, and WB

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