Publication

[Nature Structural & Molecular Biology] Researchers investigated the transcription factors regulomes during the first lineage specification in early mouse embryos, spanning the pre-initiation, initiation, commitment, and maintenance phases.

[Cell] Scientists developed a bispecific DC-T cell engager, a reagent that facilitated physical interactions between PD-1+ T cells and conventional type I dendritic cells.

[EMBO Molecular Medicine] In immunocompetent mice, intraperitoneal administration of IL-33 could induce a celiac inflammatory environment, activated immunologic effector cells, and reverse the immunosuppressive tumor microenvironment, which effectively delayed tumor progression and peritoneal metastasis of gastric cancer.

[eLife] Scientists developed a novel and versatile immune monitoring strategy by adding a short cysteine-rich tag to antigenic peptides that emited fluorescence upon binding to thiol-reactive biarsenical hairpin compounds.

[Science Immunology] Modeling initial T-dependent B cell activation with CD40L en vitro, researchers showed that FAS competent cells with transient FAS ligation showed specifically decreased mTOR axis activation without apoptosis.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists developed an antibody (15B6) that bound next to the membrane at the protease-sensitive region, did not bind to shed mesothelin, and made CAR-T cells that had much higher anti-tumor activity than a CAR-T that binds to shed mesothelin.