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Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

[Advanced Science] The suitability of the microfluidic device for dynamic 3D cell culture was tested by growing human hepatocytes in the device under controlled fluid flow for a 14-day period.

Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy

[Advanced Science] Researchers demonstrated that microfluidic patient-derived cancer organoids were phenotypically and genotypically similar to the gold-standard Matrigel organoids with the advantages of 1) spheroid uniformity, 2) minimal cell number requirement, and 3) not relying on Matrigel.

Vasculature-on-a-Chip with a Porous Membrane Electrode for In Situ Electrochemical Detection of Nitric Oxide Released from Endothelial Cells

[Analytical Chemistry] A porous gold membrane electrode was placed directly beneath the cells for in situ and real-time measurements of nitrous oxide.

Amplification of poly(I:C)-Induced Interleukin-6 Production in Human Bronchial Epithelial Cells by Priming With Interferon-γ

[Scientific Reports] Researchers showed that pretreatment of human bronchial epithelial cells with interferon-γ markedly increased IL-6 production induced by the toll-like receptor 3 agonist poly(I:C) from 0.4 ± 0.1 to 4.1 ± 0.4 ng/mL.

A Novel Lung Cancer Stem Cell Extracellular Vesicles lncRNA ROLLCSC Modulate Non-Stemness Cancer Cell Plasticity through miR-5623-3p and miR-217-5p Targeting Lipid Metabolism

[International Journal Of Biological Macromolecules] The authors demonstrated that the pro-metastatic activity of ROLLCSC was achieved through its function as a competing endogenous RNA of miR-5623-3p and miR-217-5p to stimulate lipid metabolism.

Telomere Shortening Induces Aging-Associated Phenotypes in hiPSC-Derived Neurons and Astrocytes

[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.

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