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S100A9 Exerts Insulin-Independent Antidiabetic and Anti-Inflammatory Effects
[Science Advances] Researchers reported an insulin signaling–independent pathway able to improve glycemic control in Type 1 diabetes mellitus rodents.
Hematopoiesis News
MarrowCellDLD: A Microfluidic Method for Label-Free Retrieval of Fragile Bone Marrow-Derived Cells
[Scientific Reports] MarrowCellDLD enabled the isolation of large, fragile bona marrow-derived cells based on intrinsic size properties while preserving their viability and functionality.
Hematopoiesis News
CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia Is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216
[Blood Advances] Investigators established CD34+ cord blood–derived CBFA2T3::GLIS2models that sustained serial transplantation and recapitulated human leukemia regarding immunophenotype, leukemia-initiating cell frequencies, comutational landscape.
Intestinal Cell News
Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids
[Science Of The Total Environment] Researchers used a mouse intestinal organoid combined with cell model to explore the differences in metabolites and toxicity mechanisms induced by exposure to three nanoplastics.
Cell Therapy News
Synovial Mesenchymal Stem Cell-Derived Exosomal miR-485-3p Relieves Cartilage Damage in Osteoarthritis by Targeting the NRP1-Mediated PI3K/Akt Pathway
[Heliyon] Cartilage cell functions were detected by CCK-8, scratch assay, and flow cytometry, respectively. Inflammatory cytokine levels were assessed by ELISA. Target molecule levels were measured by qRT‒PCR and Western blotting.
Cell Therapy News
Label-Free Enrichment of Human Pluripotent Stem Cell-Derived Early Retinal Progenitor Cells for Cell-Based Regenerative Therapies
[Stem Cell Reports] Scientists enabled the enrichment of wild-type retinal progenitor cells (RPCs) from dissociated retinal organoids using a label-free ghost cytometry-based sorting system, where a machine-based classifier was trained in advance with another RPC reporter line.