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Immune Regulation News
Distinct Use of Super-enhancer Elements Controls Cell Type–Specific CD25 Transcription and Function
[Science Immunology] The authors investigated CD25 regulation and function using a series of mice with deletions spanning STAT5-binding elements.
Immune Regulation News
IL-21R-STAT3 Signaling Initiates a Differentiation Program in Uterine Tissue-Resident NK Cells to Support Pregnancy
[Nature Communications] Investigators characterized uterine tissue-resident Natural Killer cells longitudinally during pregnancy by single cell RNA sequencing and found that the combined expression pattern of 4-1BB and CD55 defined their three distinct stages of differentiation in mice.
Immune Regulation News
Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity
[Nature Communications] By comprehensively mapping 3D chromatin organization during Treg cell differentiation, scientists showed that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression.
Immune Regulation News
Target ssDNA Activates the NADase Activity of Prokaryotic SPARTA Immune System
[Nature Chemical Biology] Researchers used cryo-electron microscopy to determine the structures of inactive monomeric and active tetrameric Crenotalea thermophila short prokaryotic Ago/TIR–APAZ (SPARTA) complexes.
Immune Regulation News
RANKL/RANK Is Required for Cytokine-Induced Beta Cell Death; Osteoprotegerin, a RANKL Inhibitor, Reverses Rodent Type 1 Diabetes
[Science Advances] Investigators demonstrated that the receptor activator of nuclear factor kappa Β (NF-κB) (RANK) pathway mediated cytokine-induced rodent and human β cell death through RANK-tumor necrosis factor receptor–associated factor 6 interaction and induction of NF-κB activation.
Immunology of Infectious Disease News
SARS-CoV-2 Viral Persistence in Lung Alveolar Macrophages Is Controlled by IFN-γ and NK Cells
[Nature Immunology] Investigators used a model of viral infection in macaques to address whether SARS-CoV-2 persists in the body and which mechanisms regulate its persistence.