Tag results:

Publication

Prosaposin Maintains Adult Neural Stem Cells in a State Associated with Deep Quiescence

[Stem Cell Reports] Using RNA sequencing and pharmacological manipulations, investigators showed that lysosomes were necessary for neural stem cell quiescence maintenance.

Dux Activates Metabolism-Lactylation-MET Network during Early iPSC Reprogramming with Brg1 as the Histone Lactylation Reader

[Nucleic Acids Research] Scientists demonstrated that the modification of H3K18la induced by Dux overexpression controlled the metabolism-H3K18la-MET network, enhancing the efficiency of iPSC reprogramming through a metabolic switch and the recruitment of p300 via its C-terminal domain.

Preparation of Human Astrocytes with Potent Therapeutic Functions from Human Pluripotent Stem Cells Using Ventral Midbrain Patterning

[Journal of Advanced Research] To substantiate the clinical application of astrocyte-based therapy, researchers prepared human astrocytes with potent therapeutic capacities from hPSCs. They used ventral midbrain patterning during the differentiation of hPSCs into astrocytes.

Matrix-Free Human Pluripotent Stem Cell Manufacturing by Seed Train Approach and Intermediate Cryopreservation

[Stem Cell Research & Therapy] Stirred tank bioreactors-controlled, chemical aggregate dissociation, and optimized passage duration of three or four days promoted exponential hPSC proliferation, process efficiency, and upscaling by a seed train approach.

Spatial Cell Fate Manipulation of Human Pluripotent Stem Cells by Controlling the Microenvironment Using Photocurable Hydrogel

[Development] Investigators cultured hPSCs on hydrogel substrates with spatially controlled stiffness. The use of culture substrates that enabled precise manipulation of spatial mechanical properties held promise for better mimicking in vivo conditions and advancing tissue engineering techniques.

Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived Neurospheres

[Regenerative Therapy] Scientists evaluated the efficiency of cryopreservation using DEPAK and Proton freezers, both of which are used in the food industry, compared with conventional slow-freezing methods using a programmable freezer and a cell-freezing vessel.

Popular