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Third-Generation Rabies Viral Vectors Allow Nontoxic Retrograde Targeting of Projection Neurons with Greatly Increased Efficiency

[Cell Reports Methods] Researchers introduced third-generation rabies viral vectors, which appearred to be as nontoxic as second-generation ones but have the major advantage of growing to much higher titers, resulting in significantly increased numbers of retrogradely labeled neurons in vivo.

NOCICEPTRA2.0 – A Comprehensive ncRNA Atlas of Human Native and iPSC-Derived Sensory Neurons

[iScience] Investigators created a comprehensive atlas of small ncRNA species during iPSC-derived sensory neuron differentiation. Utilizing iPSC-derived sensory neurons and human DRG RNA sequencing, they unveiled signatures describing developmental processes.

Pregnancy-Responsive Pools of Adult Neural Stem Cells for Transient Neurogenesis in Mothers

[Science] The authors showed that multiple regionally distinct neural stem cells, including domains that are usually quiescent, are recruited on different gestation days during pregnancy.

TRPV4 Blockade Alleviates Endoplasmic Reticulum Stress Mediated Apoptosis in Hypoxia–Induced Cardiomyocyte Injury

[Cellular Signalling] The ability of transient receptor potential vanilloid 4 (TRPV4) to modulate the endoplasmic reticulum stress and apoptosis was assessed in vitro through the administration of the TRPV4 antagonist HC-067047 or the agonist GSK1016790A.

Oxidative Stress Drives Vascular Smooth Muscle Cell Damage in Acute Stanford Type A Aortic Dissection through HIF-1α/HO-1 Mediated Ferroptosis

[Heliyon] Bioinformatic analyses and experimental validation were performed to reveal ferroptosis and HO-1 expression in acute Stanford type A aortic dissection.

Serine Synthesis Pathway Enzyme PHGDH Is Critical for Muscle Cell Biomass, Anabolic Metabolism, and mTORC1 Signaling

[American Journal Of Physiology-Endocrinology And Metabolism] Scientists identified enzymes that limited protein synthesis, myotube size, and proliferation in skeletal muscle cells.

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