Publication

[Science Advances] Investigators demonstrated that iron deficiency-mediated ferritinophagy impeded myogenic differentiation. Mechanistically, ferritinophagy induced RNF20 degradation through the autophagy-lysosomal pathway.

[Nucleic Acids Research] Researchers explored a strategy to select optimal guide RNAs using their pooled data on CRISPR/Cas9-mediated gene knockout in human T cells.

[Molecular Cell] Investigators showed that epidermal growth factor receptor (EGFR) signaling repressed N6-methyladenosine (m6A) levels in glioblastoma stem cells, whereas genetic or pharmacologic EGFR targeting elevated m6A levels.

[American Journal Of Physiology-Gastrointestinal And Liver Physiology] The authors recorded neuromuscular transmission to the circular muscle using intracellular microelectrodes to investigate the spread of influence of intrinsic motor neurons.

[Advanced Healthcare Materials] Scientists presented a hybrid endometrial-derived hydrogel that combined the rigidity of PuraMatrix with the natural scaffold components and interactions of a decellularized porcine endometrial extracellular matrix hydrogel.

[Nature Communications] Researchers reported that the lncRNA INHEG was highly expressed in glioma stem cells (GSCs) compared to differentiated glioma cells and promoted GSC self-renewal and tumorigenicity through control of rRNA 2’-O-methylation.