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Discovery of 3-Phenyl Indazole-Based Novel Chemokine-Like Receptor 1 Antagonists for the Treatment of Psoriasis

[Journal Of Medicinal Chemistry] In the imiquimod-induced psoriasis-like mouse model, oral administration of the optimized compound for one week significantly alleviated modified psoriasis area and severity index scores, compared with the control group.

The JAK/STAT/NF-κB Signaling Pathway Can Be Regulated by Rosemary Essential Oil, Thereby Providing a Potential Treatment for DNCB-Induced in Mice

[Biomedicine & Pharmacotherapy] A dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model was established and treated with low, medium, and high doses of Rosmarinus officinalis essential oil.

Bioengineered Skin Constructs Based on Mesenchymal Stromal Cells and Acellular Dermal Matrix Exposed to Inflammatory Microenvironment Releasing Growth Factors Involved in Skin Repair

[Stem Cell Research & Therapy] Researchers developed a novel method involving physicochemical and enzymatic treatment of cadaveric human skin to obtain human acellular dermal matrix scaffold.

Single-Atom Catalysts-Based Catalytic ROS Clearance for Efficient Psoriasis Treatment and Relapse Prevention via Restoring ESR1

[Nature Communications] Scientists showed that biomimetic iron single-atom catalysts with broad-spectrum reactive oxygen species (ROS) scavenging capability could be used for psoriasis treatment and relapse prevention via related gene restoration.

Mechanical Stimulation of Human Hair Follicle Outer Root Sheath Cultures Activates Adjacent Sensory Neurons

[Science Advances] Using electrochemical analysis on human hair follicle preparations in vitro, researchers were able to show that outer root sheath cells released ATP and the neurotransmitters serotonin and histamine in response to mechanical stimulation.

Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair

[Circulation] Researchers used apical resection and myocardial infarction surgical models in neonatal and adult mice to investigate extracellular matrix components involved in heart regeneration after injury.

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