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TLR9 Ligand Sequestration by Chemokine CXCL4 Negatively Affects Central B Cell Tolerance

[Journal Of Experimental Medicine] The authors showed that CXCL4, a chemokine involved in systemic sclerosis, abrogated TLR9 function in B cells by sequestering TLR9 ligands away from the endosomal compartments where this receptor resides.

Intratumoral Co-Injection of NK Cells and NKG2A-Neutralizing Monoclonal Antibodies

[EMBO Molecular Medicine] Scientists found that intratumoral delivery of NK cells attained significant therapeutic effects only if co-injected with anti-NKG2A and anti-Qa-1b blocking monoclonal antibodies against solid mouse tumor models.

NKG2D-Mediated Detection of Metabolically Stressed Hepatocytes by Innate-Like T Cells Is Essential for Initiation of NASH and Fibrosis

[Science Immunology] Tissue-resident innate-like T cells, most notably γδ T cells, were activated through NKG2D and secreted IL-17A. IL-17A licensed hepatocytes to produce chemokines that recruited proinflammatory cells into the liver, which caused nonalcoholic steatohepatitis and fibrosis.

Laboratory Mice with a Wild Microbiota Generate Strong Allergic Immune Responses

[Science Immunology] To uncover the impact of lifelong microbial exposure on the development of allergic inflammation, researchers compared experimental wildling mice, which have a representative breadth of naturally occurring pathogens, to specific pathogen–free mice.

Effector Memory T Cells Induce Innate Inflammation by Triggering DNA Damage and a Non-Canonical STING Pathway in Dendritic Cells

[Cell Reports] Researchers reported the surprising discovery that T effector memory cells triggered double-strand DNA breaks via mitochondrial reactive oxygen species production in interacting dendritic cells.

USP47 Inhibits m6A-Dependent C-Myc Translation to Maintain Regulatory T Cell Metabolic and Functional Homeostasis

[Journal Of Clinical Investigation] USP47 ablation compromised Treg cell homeostasis and function in vivo, resulting in the development of inflammatory disorders, and boosted antitumor immune responses.

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