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Development and Characterisation of Suitably Bioengineered Microfibrillar Matrix-Based 3D Prostate Cancer Model for In Vitro Drug Testing

[Biomedical Materials] Microfibrillar matrices were fabricated as 3D spherical and disc-shaped scaffolds with highly interconnected pores and the potential of the newly developed scaffolds for developing prostate cancer model has been investigated.

Polyphyllin I Induces Ferroptosis in Castration-Resistant Prostate Cancer Cells through the ERK/DNMT1/ACSL4 Axis

[The Prostate] Polyphyllin I (PPI), one of the steroidal saponins in paris polyphylla, has been shown to have an anticancer effect. Researchers investigated the role and mechanism of PPI in CRPC cell ferroptosis.

Docetaxel Radiosensitizes Castration Resistant Prostate Cancer by Downregulating CAV-1

[International Journal of Radiation Biology] The authors investigated the effectiveness and molecular characteristics of docetaxel and radiation combination therapy in vitro.

Sennoside a Induces Autophagic Death of Prostate Cancer via Inactivation of PI3K/AKT/mTOR Axis

[Journal of Molecular Histology] Investigators detected the toxicity of sennoside A (SA) on PC3 and DU 145 cells via CCK-8. The effects of SA on growth, apoptosis, and autophagy were determined through additional examinations.

miR-199a/214 Cluster Enhances Prostate Cancer Sensitiveness to Nimotuzumab via Targeting TBL1XR1

[Kaohsiung Journal Of Medical Sciences] To investigate the molecular mechanisms underlying the effects of nimotuzumab on prostate cancer development, the authors focused on the miR-199a-5p and miR-214-3p miRNA clusters.

A Robust Deep Learning Workflow to Predict CD8+ T Cell Epitopes

[Genome Medicine] The authors developed TRAP (T-cell recognition potential of HLA-I presented peptides), a robust deep learning workflow for predicting CD8 T cell epitopes from MHC-I presented pathogenic and self-peptides.

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