Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] BRD4 directly stimulated transcripts expression of seven methyltransferase complex subunits, allowing the maintenance of the nuclear writer complex integrity.

[Haematologica] Scientists showed that TWIST1 was extremely highly expressed in the LSCs of MLL-AF9+ acute myeloid leukemia, and its upregulation was positively regulated by KDM4C in an H3K9me3 demethylation-dependent manner.

[JCI Insight] The authors showed that clinical samples of primary invasive carcinoma and chemoresistant breast cancer metastasis contain a unique hybrid cancer cell population coexpressing pancytokeratin and the MSC marker fibroblast activation protein-α.

[Cellular And Molecular Life Sciences] Researchers demonstrated that TrkB was significantly upregulated in highly metastatic hepatocellular carcinoma (HCC) cells and HCC patients. The increased TrkB levels were significantly correlated with tumor stages and poor survival of HCC patients.

[Cell Communication And Signaling] The structure, sequence and downstream target miRNAs of lncRNA Mir100hg were predicted by online web resources. The bioinformatics prediction results were validated with experimental verification.

[Inflammation And Regeneration] To develop innovative materials that recapitulated the CSC niche in pancreatic cancers, researchers performed polymer microarray analysis to identify niche-mimicking scaffolds that preferentially supported the growth of CSCs.