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Combination of RUNX1 Inhibitor and Gemcitabine Mitigates Chemo-Resistance in Pancreatic Ductal Adenocarcinoma by Modulating BiP/PERK/eIF2α-Axis-Mediated Endoplasmic Reticulum Stress

[Journal Of Experimental & Clinical Cancer Research] Scientists constructed the stably expressing cell lines with shRUNX1 and RUNX1, and successfully established Gemcitabine (GEM)-resistant cell line. The role of RUNX1 in GEM resistance was determined by CCK8 assay, plate colony formation assay and apoptosis analysis in vitro and in vivo.

Truncated Vitronectin with E-Cadherin Enables the Xeno-Free Derivation of Human Embryonic Stem Cells

[Scientific Reports] Three hESC lines were successfully derived on the vitronectin with a truncated N-terminus in combination with E-cadherin in xeno-free conditions for the first time, and their undifferentiated state, hESC morphology, and standard karyotypes together with their potential to differentiate into three germ layers were confirmed.

Molecular Mechanism of De Novo Replication by the Ebola Virus Polymerase

[Nature] Using Ebola virus (EBOV) L polymerase as a representative, investigators showed that de novo replication of L polymerase was controlled by the specific 3’ leader sequence of EBOV genome in an enzymatic assay, and formation of at least three base pairs can effectively drive the elongation process of RNA synthesis independent of the specific RNA sequence.

A Mosaic Influenza Virus-Like Particles Vaccine Provides Broad Humoral and Cellular Immune Responses Against Influenza a Viruses

[NPJ Vaccines] Researchers demonstrated the mosaic vaccines induced stronger cross-reactive antibodies and robust more T cell responses compared to the quadrivalent inactivated influenza vaccine.

CD8+T Cell Infiltration and Proliferation in the Brainstem During Experimental Cerebral Malaria

[CNS Neuroscience & Therapeutics] To explore cell composition and CD8+ T cell infiltration during cerebral malaria, single-cell RNA sequencing was performed on the brainstems of healthy and experimental cerebral malaria mice.

Design of a Novel Multiepitope Vaccine Against Chlamydia pneumoniae Using the Extracellular Protein as a Target

[Scientific Reports] Researchers selected the MOMP protein of C. pneumoniae as the antigen target, predicted the T and B cell epitopes of the MOMP protein and then connected the CTLA-4 extracellular structure with the predicted dominant epitopes by various linkers to construct a multi-epitope vaccine.

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