Publication

[Stem Cell Reviews and Reports] Investigators showed that exposure of frozen human blastocysts to an inhibitor of checkpoint kinase 1 (CHK1) upon thaw greatly enhanced establishment of karyotypically normal late naïve human ESC cultures.

[Molecular Therapy-Methods & Clinical Development] Scientists presented the development of truncated T cell receptor (TCR) α and TCRβ chains, termed "Mini-TCRs". They successfully induced cytotoxic T lymphocytes from iPSCs by employing Mini-TCRs.

[Frontiers in Neuroscience] Building upon previous work that demonstrated the rapid establishment of a primitive ectoderm population from hiPSCs, researchers described the production of a diverse population of both ventral spinal and dorsal horn progenitor cells.

[Journal of Neural Engineering] The authors investigated whether and how the balance between excitation and inhibition influenced the spontaneous development of human-derived neuronal networks in vitro.

[Frontiers in Physiology] Scientists identified two myotonic dystrophy type 1 patients with heart conduction abnormalities and characterized their hiPSC lines.

[Advanced Healthcare Materials] Investigators cultured circulating tumor cells (CTC)-like DU4475 triple negative breast cancer cells in mechanically tunable 3D fibrin hydrogel scaffolds. They showed that fibrin hydrogels supported DU4475 cell growth, resulting in spheroid formation.