Publication

[Science Translational Medicine] The development of cystic tissue required the activation of transforming growth factor–β (TGFβ) signaling, which promoted the expression of a procystic, fibronectin-rich ECM and which itself was perceived by a changing profile of integrin receptors on the cystic epithelium.

[Science Translational Medicine] Investigators fabricated bioengineered cartilage rings from three-dimensionally printed fibers of poly(ɛ-caprolactone) and rabbit chondrocytes.

[Biomedicine & Pharmacotherapy] Lysyl oxidase (LOX) conditions ECM biomechanical properties, and was upregulated in calcified valves from two cohorts of calcific aortic valve disease patients.

[Advanced Science] A scalable system was proposed to generate pre-vascularized and functional human beige adipose tissue organoids using the human stromal vascular fraction of white adipose tissue as a source of adipose and endothelial progenitors.

[Frontiers in Cell and Developmental Biology] Investigators performed a detailed functional characterization of human intestinal organoid cultures under different conditions with the aim to suggest an optimized ex-vivo model to further analyze inflammation-induced intestinal epithelial barrier dysfunction.

[Frontiers in Cell and Developmental Biology] The authors assessed the effect of cigarette smoke-exposure and the endoplasmic reticulum stress inducer Thapsigargin on Wnt/β-catenin signaling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation.