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Netrin-1 Blockade Inhibits Tumor Associated Myeloid-Derived Suppressor Cells and Cancer Stemness and Alleviates Resistance to Chemotherapy and Immune Checkpoint Inhibitor

[Cell Death & Differentiation] Scientists showed that netrin-1 was an independent prognostic marker for clinical progression of breast and ovary cancers. They found a significant correlation between netrin-1 expression and CSC markers levels.

Targeting LGSN Restores Sensitivity to Chemotherapy in Gastric Cancer Stem Cells by Triggering Pyroptosis

[Cell Death & Disease] Researchers presented evidence that lengsin, lens protein with glutamine synthetase domain (LGSN), was overexpressed in gastric CSCs and was highly correlated with malignant progression and poor survival in gastric cancer patients.

SPDEF Enhances Cancer Stem Cell-Like Properties and Tumorigenesis through Directly Promoting GALNT7 Transcription in Luminal Breast Cancer

[Cell Death & Disease] The expressions and clinicopathological characteristics of SAM pointed domain containing ETS transcription factor (SPDEF) in luminal breast cancer patients were evaluated bioinformatically.

TRPM7 Transactivates the FOSL1 Gene through STAT3 and Enhances Glioma Stemness

[Cellular And Molecular Life Sciences] Investigators determined the effects of FOSL1 on glioma stem cell markers CD133 and ALDH1 by flow cytometry and the maintenance of stem cell activity by extreme limiting dilution assays.

WNT2–SOX4 Positive Feedback Loop Promotes Chemoresistance and Tumorigenesis by Inducing Stem-Cell Like Properties in Gastric Cancer

[Oncogene] The authors found that overexpression of WNT2 enhanced stemness properties to promote chemoresistance and tumorigenicity in gastric CSCs.

The Role of m6A-Modified CircEPHB4 in Glioma Pathogenesis: Insights Into Cancer Stemness Metastasis

[Annals of Clinical and Translational Neurology] The mRNA and protein expression were tested by qRT-PCR and Western blot, respectively. ChIP assay was performed to detect SRY-box transcription factor 2 enrichment on the Pleckstrin Homology Like Domain Family B Member 2 promoter.

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