Publication

[Cell & Bioscience] Due to the high similarity with humans, the authors generated leptin-deficient pigs to investigate the mechanisms and clinical trials of obesity and non-alcoholic fatty liver disease (NAFLD) caused by leptin.

[Molecular Cancer Therapeutics] Upon the successful establishment of a battery of cellular models developing resistance to FGFR4 inhibitors, researchers identified the activation of EGFR, MAPK, and AKT signaling as the primary mechanisms mediating the acquired resistance.

[Hepatology Communications] Through in vivo CRISPR knockout screens targeting related E3 ligase genes in HCC nude mice models, investigators discovered Listerin (LTN1) as a novel tumor suppressor in HCC.

[Journal Of Biomolecular Structure & Dynamics] Pharmacophore-based virtual screening of a small molecule database was performed initially, and then the screened hits were docked to the active site of SIRT3 to choose the best binding modes.

[Scientific Reports] Investigators examined the ameliorative effects of camel milk and silymarin supplementation upon aflatoxin B1 induced hepatic injury in rats.

[Nutrition & Metabolism] Analysis using dot blot and epitranscriptomic chips revealed that the m6A modification pattern of the transcriptome in high-fat diet-induced fatty liver and free fatty acid-induced fatty hepatocytes showed significant changes.