Publication

[Haematologica] In dedicated experimental models of allogeneic hematopoietic stem cell transplantation the authors evaluated side-by-side the therapeutic effect of two IL-2/anti-IL-2 complexes designed either to boost Tregs, or alternatively to activate effector T cells Teffs, on GVHD occurrence and tumor relapse.

[Science Advances] Investigators developed a general mathematical framework for the data-driven analysis of collective immune cell dynamics.

[Cancer Immunology Research] Scientists showed that, after coculture with target cells coated with anti-CD20 or anti-CD38, slan+ monocytes mediated trogocytosis, a cell–cell contact dependent, antibody-mediated process that triggers an active, mechanic disruption of target cell membranes.

[Journal Of Experimental Medicine] Loss of the guanine nucleotide exchange factor Rin-like led to an increase of Tfh in aging, upon in vivo immunization and acute LCMV Armstrong infection in mice, and in human CD4+ T cell in vitro cultures.

[Cell Reports] Researchers investigated whether lipolysis-stimulated lipoprotein receptor (LSR) contributed to intestinal epithelium homeostasis and pathogenesis of intestinal disease. By using multiple conditional deletion mouse models and ex vivo cultured organoids, they find that LSR elimination in intestinal stem cells results in the disappearance of Paneth cells without affecting the differentiation of other cell lineages

[Journal Of Ethnopharmacology] Scientists investigated the restorative effect and mechanism of Shen-Ling-Bai-Zhu-San on disturbed intestinal homeostasis in dextran sulfate sodium-induced colitis mice.