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Activation of cAMP (EPAC2) Signaling Pathway Promotes Hepatocyte Attachment

[Scientific Reports] Investigators reported a novel use of a medium designed for induced pluripotent stem cell-derived hepatocytes, increasing primary human hepatocyte attachment on the collagen matrix.

METTL1 Promotes Tumorigenesis Through tRNA-Derived Fragment Biogenesis in Prostate Cancer

[Molecular Cancer] Investigators showed that the transfer RNA N7-methylguanosine (m7G) transferase METTL1 was highly expressed in primary and advanced prostate tumors. Mechanistically, they found that METTL1 depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments.

Gain-of-Function Mutant p53 Together with ERG Proto-Oncogene Drive Prostate Cancer by Beta-Catenin Activation and Pyrimidine Synthesis

[Nature Communications] Researchers demonstrated that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in prostate cancer patient specimens and this co-occurrence accelerates prostatic oncogenesis.

Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis

[Cancer Research] Scientists demonstrated that acute treatment with the antiandrogen enzalutamide decreased glutathione production, increased lipid peroxidation, and induced ferroptosis in prostate cancer cells.

A GATA2-CDC6 Axis Modulates Androgen Receptor Blockade-Induced Senescence in Prostate Cancer

[Journal Of Experimental & Clinical Cancer Research] Assessment of the invasive potential of cells and senescence status following enzalutamide treatment and/or RNAi-mediated silencing of selected targets was performed in all cell lines, complemented by bioinformatics analyses on a wide range of in vitro and in vivo datasets.

SQLE Promotes Pancreatic Cancer Growth by Attenuating ER Stress and Activating Lipid Rafts-Regulated Src/PI3K/Akt Signaling Pathway

[Cell Death & Disease] Scientists found that squalene epoxidase (SQLE) was a crucial mediator of cholesterol metabolism in prostate cancer growth. They observed a profound upregulation of SQLE in prostate cancer tissues, and its high expression was correlated with poor patient outcomes.

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