Publication

[Cancer Immunology Immunotherapy] Researchers described an engineered cell with both dual targeting and orthogonal cytotoxic modalities directed against two tumor antigens that are highly expressed on ovarian cancer cells: cell surface Muc16 and intracellular WT1.

[Transplantation And Cellular Therapy] Investigators performed a retrospective ‘real world’ analysis of a multicentre cohort of myelofibrosis allogeneic hematopoietic cell transplantation patients from 8 European transplant centers who received donor lymphocyte infusions between 2005-2022.

[Advanced Healthcare Materials] When interacting with inflammatory vascular endothelial cells, sphingosine-1-phosphate (S1P) molecules encapsulated in cyclodextrin cavities exhibited a rapid, excellent, and stable targeting effect owing to their specific interaction with the highly expressed S1P receptor 1 on the inflammatory vascular endothelial cells.

[eLife] Investigators found that SAM68, an Src associated in mitosis, was transiently localized at the edge of spreading cells, where it participated in membrane protrusive activity and the conversion of nascent adhesions to mechanically loaded focal adhesions by modulation of integrin signaling and local delivery of β-actin mRNA.

[Circulation Research] The involvement of sentrin-specific protease 1-mediated SUMOylation in mitochondrial remodeling in the pulmonary endothelium was identified in clinical specimens of hypoxia-related pulmonary hypertention, and was verified in human pulmonary artery endothelial cells under hypoxia.

[Journal Of Clinical Investigation] Scientists showed that split end (SPEN), a transcription repressor, coordinated ribosome RNA synthesis in endothelial cells and was required for physiological and tumor angiogenesis.