Publication

[Circulation] Disease progression was quantified by tail-volumetric and -histopathologic measurements over time. Lymphatic endothelial cells from mice and humans, with S1P signaling inhibition, were then cocultured with CD4 T cells, followed by an analysis of CD4 T-cell activation and pathway signaling.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers reported a Col4a1 mutant mouse model of cerebral small vessel disease with age-dependent defects in capillary-to-arteriole dilation, functional hyperemia in the brain, and memory.

[Translational Stroke Research] The authors compared the transcriptomic profiles among three different types of control vessels: superficial temporal artery, middle cerebral arteries, and arteries from the circle of Willis obtained from autopsies.

[Journal Of Heart And Lung Transplantation] Investigators analyzed single-cell RNA sequencing data and constructed an inducible lineage tracing mouse, combined heart transplantation with bone marrow transplantation and a parabiosis model, cellular components, and endothelial cell populations in cardiac graft lesions.

[Journal Of Experimental Medicine] Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). Researchers analyzed via single-cell omics the trajectory leading to LatY136F DLSP, and the underlying CD4+ T cell diversification.

[Cell Reports] To understand the functional impact of mutations across FoxP3 domains, without genetic and environmental confounders, six human FOXP3 missense mutations were engineered into mice.