Publication

[eLife] Investigators found that SAM68, an Src associated in mitosis, was transiently localized at the edge of spreading cells, where it participated in membrane protrusive activity and the conversion of nascent adhesions to mechanically loaded focal adhesions by modulation of integrin signaling and local delivery of β-actin mRNA.

[Circulation Research] The involvement of sentrin-specific protease 1-mediated SUMOylation in mitochondrial remodeling in the pulmonary endothelium was identified in clinical specimens of hypoxia-related pulmonary hypertention, and was verified in human pulmonary artery endothelial cells under hypoxia.

[Journal Of Clinical Investigation] Scientists showed that split end (SPEN), a transcription repressor, coordinated ribosome RNA synthesis in endothelial cells and was required for physiological and tumor angiogenesis.

[Circulation] Disease progression was quantified by tail-volumetric and -histopathologic measurements over time. Lymphatic endothelial cells from mice and humans, with S1P signaling inhibition, were then cocultured with CD4 T cells, followed by an analysis of CD4 T-cell activation and pathway signaling.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers reported a Col4a1 mutant mouse model of cerebral small vessel disease with age-dependent defects in capillary-to-arteriole dilation, functional hyperemia in the brain, and memory.

[Translational Stroke Research] The authors compared the transcriptomic profiles among three different types of control vessels: superficial temporal artery, middle cerebral arteries, and arteries from the circle of Willis obtained from autopsies.