Publication

[Endocrinology] To address the functional role of glucocorticoid receptor (GR) in the adult liver, the authors used an acute hepatocyte-specific GR knockout model to study temporal hepatic lipid metabolism governed by GR at several pre- and postprandial circadian timepoints.

[Heliyon] Through extensive statistical analyses, using liver hepatocellular carcinoma (LIHC) patient databases, investigators observed that coiled-coil domain-containing protein 115 (CCDC115) expression significantly increased in tumor tissues of LIHC patients.

[Science Advances] Researchers developed TypeTracker, which identified cell fates by AI-enabled cell tracking and propagating end point fates back along the branched lineage trees.

[Stem Cell Research & Therapy] The authors generated three-dimensional cerebral organoids from human parental iPSC lines and its isogenic apolipoprotein E (APOE)-deficient iPSC line.

[Development] Investigators found that mouse gastruloids contained posterior-to-anterior gradients of Erk and Akt phosphorylation induced by distinct receptor tyrosine kinases.

[Stem Cell Reviews and Reports] Researchers utilized the hESC derived retinal organoids (hROs) to recapitulate the initial retinal neurogenesis and found that 1% (v/v) ethanol slowed the growth of hROs by inducing robust cell death and retinal ganglion cell differentiation defect.