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A Nondepleting Anti-CD19 Antibody Impairs B Cell Function and Inhibits Autoimmune Diseases

[JCI Insight] Scientists described a nondepleting, high-affinity anti–human CD19 antibody LY3541860 that exhibited potent B cell inhibitory activities. LY3541860 inhibited B cell activation, proliferation, and differentiation of primary human B cells with high potency.

S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Anti-Tumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells

[Molecular Cancer Therapeutics] Investigators developed a novel humanized anti-CCR8 monoclonal antibody, S-531011, aimed as a cancer immunotherapy strategy for patients with cancer.

Gain and Loss of Function Variants in EZH1 Disrupt Neurogenesis and Cause Dominant and Recessive Neurodevelopmental Disorders

[Nature Communications] Researchers uncovered and functionally defined pathogenic variants in the chromatin modifier EZH1 as the cause of dominant and recessive neurodevelopmental disorders in 19 individuals.

Spatial Transcriptomics-Correlated Electron Microscopy Maps Transcriptional and Ultrastructural Responses to Brain Injury

[Nature Communications] Scientists characterized in situ ultrastructural and transcriptional responses of glial cells and infiltrating T cells after demyelinating brain injury in male mice. THey identified a population of lipid-loaded “foamy” microglia located in the center of remyelinating lesion.

Nerve Growth Factor Receptor (Ngfr) Induces Neurogenic Plasticity by Suppressing Reactive Astroglial Lcn2/Slc22a17 Signaling in Alzheimer’s Disease

[NPJ Regenerative Medicine] Investigators used APP/PS1dE9 mouse model and induced Ngfr expression in the hippocampus. Ngfr, which promotes neurogenic fate of astroglia during the amyloid pathology-induced neuroregeneration in zebrafish brain, stimulated proliferative and neurogenic outcomes.

ASH2L Regulates Postnatal Neurogenesis Through Onecut2-Mediated Inhibition of TGF-β Signaling Pathway

[Cell Death & Differentiation] Researchers reported that Absent, small or homeotic discs-like 2 (Ash2l), one core component of a multimeric histone methyltransferase complex, was essential for neural stem/progenitor cell fate determination during postnatal neurogenesis.

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