Review

[Journal Of Clinical Investigation] The authors propose that vascular and endothelial cell abnormalities are both causal and consequential in the pathobiology of idiopathic pulmonary fibrosis and that fuller evaluation of dysregulated pathways may lead to effective therapies and a cure for this devastating disease.

[Cell Communication and Signaling] The authors summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights.

[CNS Neuroscience & Therapeutics] Scientists elaborate mammalian target of rapamycin (mTOR) signaling network mainly in the brain, point to gaps of knowledge, and define how and in which ways mTOR signaling can be connected with Alzheimer's disease pathogenesis and symptoms.

[Neurotherapeutics] Investigators include the additional preclinical studies examining the efficacy of minocycline in preclinical traumatic brain injury (TBI) models as well as recommendations for a clinical trial to test minocycline to treat TBI.

[Annual Review of Genetics] Investigators summarize the particular challenges presented by each organ system and describe how iPSC models are being used to address them.

[Cancer And Metastasis Reviews] The authors documente the critical role of the gut microbiota on the therapeutic efficacy of existing anticancer drugs by altering the cancer plasticity.