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Targeted Therapies for Previously “Undruggable” KRAS-Mutated Non–Small Cell Lung Cancer: A Review of Sotorasib and Adagrasib

[Annals Of Pharmacotherapy] The authors evaluate the safety and efficacy of the novel KRAS-targeting agents, sotorasib and adagrasib, in treating KRAS G12C-mutated NSCLC.

A New Beginning: Can Omidubicel Emerge As the Next, Viable Alternative Donor Source?

[Therapeutic Advances In Hematology] The authors focus on umbilical cord blood transplantation, benefits and barriers to using this alternative donor source, and finally the potential advancements with incorporation of omidubicel in the transplant setting for malignant and non-malignant diseases.

Therapeutic Potential in Rheumatic Diseases of Extracellular Vesicles Derived from Mesenchymal Stromal Cells

[Nature Reviews Rheumatology] In the past two decades, the therapeutic value of MSCs has been evaluated because of their regenerative potential, which is mainly attributed to the secretion of paracrine factors. Many of these factors are enclosed in extracellular vesicles that reproduce the main functions of parental cells.

The Characteristics and Medical Applications of Antler Stem Cells

[Stem Cell Research & Therapy] The authors provide a brief description of antler regeneration and the role of antler stem cells (ASCs) and describe the properties and advantages of ASCs.

Targeting Innate Immune Pathways for Cancer Immunotherapy

[Immunity] Scientists present a framework wherein distinct innate immune signaling pathways activate five key dendritic cell activities that are important for T cell-mediated immunity.

Current Status and Issues in Genomic Analysis Using EUS-FNA/FNB Specimens in Hepatobiliary–Pancreatic Cancers

[Journal Of Gastroenterology] Investigators review the transition from EUS-FNA to FNB, compare each test, and discuss the current status and issues in genomic analysis of hepatobiliary–pancreatic cancers using Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)/fine-needle biopsy (FNB) specimens.

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