Review

[Journal Of Nanobiotechnology] The development of nanocarriers for precise drug delivery to LNs has attracted a lot of interest to overcome these obstacles. Most solid tumours first spread through the lymphatic system, hence effective drug administration to these tissues is essential for better therapeutic results.

[Frontiers In Cell And Developmental Biology] Investigators review the structure of the intervertebral disc, disc degeneration, and the strengths and weaknesses of common treatment methods. They focus on the cell source, cell characteristics, mechanism of action and related experiments to summarize the umbilical cord MSCs and explore the feasibility of tissue engineering technology of umbilical cord MSCs.

[Cell And Tissue Research] Biomaterials might serve as a biomimetic structure inspired by the natural milieu, assisting the cells in establishing their natural relationships. Such a method would benefit from having ready access to an abundant reservoir of stem cells with strong tissue regeneration capacity, in addition to using biological compatible material to promote new tissue creation.

[Journal Of Biomedical Science] The impact of the diverse types of self-extracellular nucleic acids on neuroinflammatory and neurodegenerative diseases was discussed. Based on the accumulating knowledge in this field, several specific antagonistic approaches are presented that could serve as therapeutic interventions to lower the pathological outcome of the indicated brain disorders.

[European Journal of Immunology] Scientists review studies showing that skin-derived αβ T cells directly recognize CD1a proteins, and certain bound lipids, such as contact dermatitis allergens, trigger T cell responses.

[Cell Death & Disease] The authors discuss the characteristics and the biological role of epithelial-mesenchymal transition (EMT) and autophagy from a cellular perspective, explaining invasion as a survival behavior of PDAC, with the aim of providing novel insights into targeting EMT and autophagy to overcome PDAC invasion.