Review

[Nutrition & Metabolism] The authors summarize the metabolic characteristics of the development of nonalcoholic fatty liver disease (NAFLD), including glucose metabolism, lipid metabolism, and intestinal metabolism, and provide insight into pharmacological targets.

[Cellular & Molecular Immunology] The authors discuss the heterogeneity and role of neutrophils in solid organ transplantation and how neutrophils may contribute to transplant-related complications.

[Nature Reviews Nephrology] Scientists discuss the roles of Tregs in autoimmune kidney diseases and transplantation, as well as their roles more generally in autoimmune disorders and inflammatory diseases.

[Endocrinology] The authors explore the current state of understanding of chromatin architecture in breast cancer subtypes and its potential role in defining their phenotypic characteristics.

[Nature Reviews Immunology] The authors focus, first, on the limitations of existing immunotherapies for solid tumours, secondly, on how in vitro 3D immuno-oncology models are established using various technologies and thirdly, on the applications of these 3D models for comprehending the cancer.

[Reproductive Biology And Endocrinology] The authors provide a summary of the current understanding on how G protein-coupled estrogen receptor stimulation regulates some of the features of normal pregnancy, and a potential link between its signaling network and uteroplacental dysfunction in preeclampsia.