MicroRNAs in Hematopoietic Stem Cell Aging

The authors discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.
[Mechanisms of Ageing and Development]
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Advances in the Development of Gene Therapy, Noncoding RNA, and Exosome‐Based Treatments for Tendinopathy

The authors summarize the current understanding and treatments for tendinopathy. They also highlight recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer‐sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.
[Annals of the New York Academy of Sciences]
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The Role of B Cells in Heart Failure and Implications for Future Immunomodulatory Treatment Strategies

B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells.
[ESC Heart Failure]
García‐Rivas, G., Castillo, E. C., Gonzalez‐Gil, A. M., Maravillas‐Montero, J. L., Brunck, M., Torres‐Quintanilla, A., Elizondo‐Montemayor, L., & Torre‐Amione, G. (n.d.). The role of B cells in heart failure and implications for future immunomodulatory treatment strategies. ESC Heart Failure, n/a(n/a). https://doi.org/10.1002/ehf2.12744 Cite
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The Tumor Microenvironment in Cholangiocarcinoma Progression

Investigators summarize current understandings of the tumor microenvironment and intercellular communications in cholangiocarcinoma and their role in tumor progression.
[Hepatology]
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Innervation: The Missing Link for Biofabricated Tissues and Organs

The authors assert that innervation should be included as a necessary component for tissue and organ biofabrication, and that strategies to orchestrate host axonal integration are advantageous to ensure proper function, tolerance, assimilation, and bio-regulation with the recipient post-implant.
[NPJ Regenerative Medicine]
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Materials Design for Bone-Tissue Engineering

The authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modeling and treatment of injuries and disease in humans.
[Nature Reviews Materials]
Koons, G. L., Diba, M., & Mikos, A. G. (2020). Materials design for bone-tissue engineering. Nature Reviews Materials, 1–20. https://doi.org/10.1038/s41578-020-0204-2 Cite
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Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

Scientists discuss the role of nuclear focal adhesion kinase (FAK) as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment
[Experimental and Molecular Medicine]
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment | Experimental & Molecular Medicine. (n.d.). Retrieved June 12, 2020, from https://www.nature.com/articles/s12276-020-0447-4 Cite
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Prevention of Tumor Risk Associated with the Reprogramming of Human Pluripotent Stem Cells

The authors focus on the risk of tumor formation by human PSCs, and on the possible treatment options if it occurs. Potential new techniques that target epigenetic processes and chromatin regulation provide opportunities for human cancer modeling and regenerative medicine.
[Journal of Experimental & Clinical Cancer Research]
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Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

The authors address the recent advances in in vitro colorectal carcinoma (CRC) model systems, ranging from conventional CRC patient-derived models, such as conditional reprogramming-based cell cultures, to more experimental and state-of-the-art models, such as cancer-on-chip platforms or liquid biopsy.
[Cancers]
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Pancreatic Cancer Treatment: Better, but a Long Way to Go

The authors highlight the historical perspectives of pancreatic cancer treatment and outline the areas of future advancement that will assist progression towards better outcomes.
[Surgery Today]
Torphy, R. J., Fujiwara, Y., & Schulick, R. D. (2020). Pancreatic cancer treatment: better, but a long way to go. Surgery Today. https://doi.org/10.1007/s00595-020-02028-0 Cite
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DNMT1: A Key Drug Target in Triple-Negative Breast Cancer

The author presents and discusses the oncogenic functions rendered by DNA methyltransferase 1 (DNMT1) in triple negative breast cancer, and DNMT1 inhibitors targeting TNBC cells.
[Seminars in Cancer Biology]
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Endothelial-to-Mesenchymal Transition in Anticancer Therapy and Normal Tissue Damage

The authors review the role of hypoxia and reactive oxygen species as the main stimulating factors of tissue damage due to vascular damage and endothelial-to-mesenchymal transition (EndMT). They consider drugs that may be clinically useful for regulating EndMT in various diseases.
[Experimental and Molecular Medicine]
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