Immunometabolism and HIV-1 Pathogenesis: Food for Thought

The authors summarize current knowledge of the links between HIV-1 infection and immunometabolism, and they discuss the potential opportunities and challenges for therapeutic interventions.
[Nature Reviews Immunology]
Sáez-Cirión, A., & Sereti, I. (2020). Immunometabolism and HIV-1 pathogenesis: food for thought. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-0381-7 Cite
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Diversity and Function of Corticopetal and Corticofugal GABAergic Projection Neurons

Research conducted over the past 10 years has revealed that cortical GABAergic projection neurons are highly diverse in terms of molecular marker expression, synaptic targeting, activity pattern during distinct behavioural states and precise temporal recruitment relative to ongoing neuronal network oscillations.
[Nature Reviews Neuroscience]
Melzer, S., & Monyer, H. (2020). Diversity and function of corticopetal and corticofugal GABAergic projection neurons. Nature Reviews Neuroscience, 1–17. https://doi.org/10.1038/s41583-020-0344-9 Cite
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
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Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis

The authors aims to understand the biological processes, key events, and consequences regarding the hypoxia-driven metabolic adaptation of tumor cells.
[International Journal of Molecular Sciences]
Miranda-Galvis, M., & Teng, Y. (2020). Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis. International Journal of Molecular Sciences, 21(15), 5487. https://doi.org/10.3390/ijms21155487 Cite
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Clinical and Molecular Consequences of Fusion Genes in Myeloid Malignancies

The authors discuss the history, biologic effect, and clinical impact of fusion genes in the field of myeloid leukemias.
[Stem Cells]
Matsukawa, T., & Aplan, P. D. (n.d.). Clinical and Molecular Consequences of Fusion Genes in Myeloid Malignancies. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3263 Cite
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Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, Including Muscular Dystrophies

iPSC cells are laboratory-produced cells that combine the biological advantages of somatic adult and stem cells for cell-based therapy. The reprogramming of cells, such as fibroblasts, to an ESC-like state is done by the ectopic expression of transcription factors responsible for generating embryonic stem cell properties.
[International Journal of Molecular Sciences]
Gois Beghini, D., Iwao Horita, S., Cascabulho, C. M., Anastácio Alves, L., & Henriques-Pons, A. (2020). Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies. International Journal of Molecular Sciences, 21(15), 5467. https://doi.org/10.3390/ijms21155467 Cite
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Current Concepts in Tumor-Derived Organoids

Organoids offer a new and exciting platform for studying cancer and directing personalised therapies. This review highlights how organoids are shaping the future of cancer research.
[British Journal of Cancer]
Porter, R. J., Murray, G. I., & McLean, M. H. (2020). Current concepts in tumour-derived organoids. British Journal of Cancer, 1–10. https://doi.org/10.1038/s41416-020-0993-5 Cite
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Interplay between SARS-CoV-2 and the Type I Interferon Response

Scientists describe our current knowledge of the complex interplay between SARS-CoV-2 infection and the IFN system, highlighting some of the gaps that need to be filled for a better understanding of the underlying molecular mechanisms.
[PLoS Pathogens]
Ribero, M. S., Jouvenet, N., Dreux, M., & Nisole, S. (2020). Interplay between SARS-CoV-2 and the type I interferon response. PLOS Pathogens, 16(7), e1008737. https://doi.org/10.1371/journal.ppat.1008737 Cite
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Immunostimulation with Chemotherapy in the Era of Immune Checkpoint Inhibitors

Understanding the precise immunological mechanisms that underlie the efficacy of chemotherapy has the potential not only to enable the identification of superior biomarkers of response but also to accelerate the development of synergistic combination regimens that enhance the clinical effectiveness of immune checkpoint inhibitors relative to their effectiveness as monotherapies.
[Nature Reviews Clinical Oncology]
Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G. (2020). Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Nature Reviews Clinical Oncology, 1–17. https://doi.org/10.1038/s41571-020-0413-z Cite
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Clinical Value of DNA Methylation Markers in Autoimmune Rheumatic Diseases

Scientists provide an updated discussion on DNA methylation alterations in autoimmune rheumatic diseases and the advantages and disadvantages of using these markers in clinical practice.
[Nature Reviews Rheumatology]
Ballestar, E., Sawalha, A. H., & Lu, Q. (2020). Clinical value of DNA methylation markers in autoimmune rheumatic diseases. Nature Reviews Rheumatology, 1–11. https://doi.org/10.1038/s41584-020-0470-9 Cite
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Mucins in Pancreatic Cancer: A Well‐Established but Promising Family for Diagnosis, Prognosis and Therapy

The authors discuss the important roles of mucins that lead to the lethality of pancreatic adenocarcinoma, particularly MUC1, MUC4, MUC5AC and MUC16 in disease progression, and present a comprehensive analysis of the clinical application of mucins and their promising roles in cancer treatment.
[Journal of Cellular and Molecular Medicine]
Mucins in pancreatic cancer: A well‐established but promising family for diagnosis, prognosis and therapy - Wang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved August 4, 2020, from https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15684 Cite
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Structural and Functional Properties of SARS-CoV-2 Spike Protein: Potential Antivirus Drug Development for COVID-19

The authors highlight recent research advance in the structure, function and development of antivirus drugs targeting the spike protein.
[Acta Pharmacologica Sinica]
Huang, Y., Yang, C., Xu, X., Xu, W., & Liu, S. (2020). Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0485-4 Cite
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