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Exploiting Transcription Factors to Target EMT and Cancer Stem Cells for Tumor Modulation and Therapy

[Seminars In Cancer Biology] Understanding how transcription factors interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research.

Glioblastoma Stem Cell Metabolism and Immunity

[Cancer And Metastasis Reviews] The mechanisms by which glioma stem cells (GSCs) alter metabolic cues and escape elimination by immune cells are discussed, along with potential strategies to harness effector immune cells against GSCs.

Role of pH-Sensing Receptors in Colitis

[Pflugers Archiv-European Journal Of Physiology] The authors review the current knowledge on the role of proton-sensing receptors in IBD and IBD-associated fibrosis and cancer, as well as colitis-associated cancer. Scientists also describe emerging small molecule modulators of these receptors as therapeutic opportunities for the treatment of IBD.

Anti-Cancer Mechanisms of Natural Isoflavones against Melanoma

[Heliyon] Scientists summarize the research progress of isoflavones in melanoma, including anti-melanoma roles and mechanisms of isoflavones via inhibition of tyrosinase activity, melanogenesis, melanoma cell growth, invasion of melanoma cells, and induction of apoptosis in melanoma cells.

Organoid-Based Personalized Medicine: From Tumor Outcome Prediction to Autologous Transplantation

[Stem Cells] The authors focus on the recent progress concerning the use of patient-derived organoids in personalized medicine, including diagnostics and disease prognosis, treatment outcome prediction to guide therapeutic advice, and organoid transplantation or cell-based therapies.

Clonal Hematopoiesis and Its Impact on the Aging Osteo-Hematopoietic Niche

[Leukemia] Scientists review the changes in the aging bone marrow (BM) niche and the emerging evidence supporting the concept that clonal hematopoiesis can progressively alter components of the local BM microenvironment.

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