Application of Human Amniotic Epithelial Cells in Regenerative Medicine: A Systematic Review

Investigators focus on summarizing the biological characteristics of human amniotic epithelial cells, therapeutic applications, and recent advances in treating various tissue injuries and disorders.
[Stem Cell Research & Therapy]
Zhang, Q., & Lai, D. (2020). Application of human amniotic epithelial cells in regenerative medicine: a systematic review. Stem Cell Research & Therapy, 11(1), 439. https://doi.org/10.1186/s13287-020-01951-w Cite
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Nonalcoholic Steatohepatitis: The Role of Peroxisome Proliferator-Activated Receptors

The authors summarize and discuss the current literature on nonalcoholic fatty liver disease (NAFLD) as the liver manifestation of the systemic metabolic syndrome and focuses on the role of peroxisome proliferator-activated receptors in the pathomechanisms as well as in the potential targeting of disease.
[Nature Reviews Gastroenterology & Hepatology]
Francque, S., Szabo, G., Abdelmalek, M. F., Byrne, C. D., Cusi, K., Dufour, J.-F., Roden, M., Sacks, F., & Tacke, F. (2020). Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. Nature Reviews Gastroenterology & Hepatology, 1–16. https://doi.org/10.1038/s41575-020-00366-5 Cite
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Genome-Wide Gene Expression Analyses of BRCA1– and BRCA2-Associated Breast and Ovarian Tumors

To determine if gene expression analysis has been a successful approach for variant classification, the authors describe the design and comparability of 23 published gene expression studies that have profiled cells from BRCA1– and BRCA2 pathogenic variant carriers.
[Cancers]
Wiggins, G. A. R., Walker, L. C., & Pearson, J. F. (2020). Genome-Wide Gene Expression Analyses of BRCA1- and BRCA2-Associated Breast and Ovarian Tumours. Cancers, 12(10), 3015. https://doi.org/10.3390/cancers12103015 Cite
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The Molecular Basis of Mammary Gland Development and Epithelial Differentiation

Investigators provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help to understand the lineage commitment of mammary stem cells into luminal or basal epithelial cells that constitute the mammary gland.
[Seminars in Cell & Developmental Biology]
Slepicka, P. F., Somasundara, A. V. H., & dos Santos, C. O. (2020). The molecular basis of mammary gland development and epithelial differentiation. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.09.014 Cite
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The Structural Basis of Herpesvirus Entry

Scientists discuss recent insights into herpesvirus entry by analysing the structures of entry glycoproteins, including the diverse receptor-binding glycoproteins, EBV glycoprotein 42 and HCMV gH–gL–gO trimer and gH–gL–UL128–UL130–UL131A pentamer.
[Nature Reviews Microbiology]
Connolly, S. A., Jardetzky, T. S., & Longnecker, R. (2020). The structural basis of herpesvirus entry. Nature Reviews Microbiology, 1–12. https://doi.org/10.1038/s41579-020-00448-w Cite
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Pathogenesis and Multidisciplinary Management of Medication-Related Osteonecrosis of the Jaw

The TGF-β1 signalling pathway may have a key role in the development of medication-related osteonecrosis of the jaw (MRONJ). The authors summarise the pathogenesis, risk factors, imaging features, clinical staging, therapeutic methods, prevention and treatment strategies associated with MRONJ.
[International Journal of Oral Science]
He, L., Sun, X., Liu, Z., Qiu, Y., & Niu, Y. (2020). Pathogenesis and multidisciplinary management of medication-related osteonecrosis of the jaw. International Journal of Oral Science, 12(1), 1–11. https://doi.org/10.1038/s41368-020-00093-2 Cite
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When Glia Meet Induced Pluripotent Stem Cells (iPSCs)

Investigators summarize the basic characteristics of glial cells, with the focus on their classical functions, heterogeneity, and uniqueness in human species. They further review the findings from recent studies that use iPSC-derived glial cells for central nervous system disease modeling.
[Molecular and Cellular Neuroscience]
Li, L., & Shi, Y. (2020). When Glia Meet Induced Pluripotent Stem Cells (iPSCs). Molecular and Cellular Neuroscience, 103565. https://doi.org/10.1016/j.mcn.2020.103565 Cite
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Human Stem Cell-Derived Oligodendrocytes: From Humanized Animal Models to Cell Therapy in Myelin Diseases

The authors discuss the anatomical and functional benefit of grafted iPSC-progenitors over their brain counterparts, their use in disease modeling and the missing gaps that still prevent to study their biology in the most integrated way, and to translate iPSC-stem cell based therapy to the clinic.
[Seminars in Cell & Developmental Biology]
Mozafari, S., & Baron-Van Evercooren, A. (2020). Human stem cell-derived oligodendrocytes: From humanized animal models to cell therapy in myelin diseases. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.09.011 Cite
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Post-Translational Modification of KRAS: Potential Targets for Cancer Therapy

The authors summarize the regulatory mode of post-translational modifications on KRAS. They also highlight the recent studies targeting these modifications having exhibited potent anti-tumor activities, including in prostate cancer.
[Acta Pharmacologica Sinica]
Wang, W., Yuan, T., Qian, M., Yan, F., Yang, L., He, Q., Yang, B., Lu, J., & Zhu, H. (2020). Post-translational modification of KRAS: potential targets for cancer therapy. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-00542-y Cite
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Endothelial Dysfunction in Neuroprogressive Disorders- Causes and Suggested Treatments

On the basis of the above molecular mechanisms, details are given of potential treatment options for mitigating endothelial cell dysfunction and activation in neuroprogressive disorders.
[BMC Medicine]
Morris, G., Puri, B. K., Olive, L., Carvalho, A., Berk, M., Walder, K., Gustad, L. T., & Maes, M. (2020). Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments. BMC Medicine, 18(1), 305. https://doi.org/10.1186/s12916-020-01749-w Cite
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Genomic Instability in Circulating Tumor Cells

The authors focus on the contribution of chromosome instability studies to genetic heterogeneity in circulating tumor cells (CTCs) at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.
[Cancers]
Freitas, M. O., Gartner, J., Rangel-Pozzo, A., & Mai, S. (2020). Genomic Instability in Circulating Tumor Cells. Cancers, 12(10), 3001. https://doi.org/10.3390/cancers12103001 Cite
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