Plasticity of Paneth Cells and Their Ability to Regulate Intestinal Stem Cells

The authors summarize key signaling pathways that affect Paneth cell (PC) differentiation and mutual effect with intestinal stem cells. In this review, they introduce the diverse functions of PCs in the intestine.
[Stem Cell Research & Therapy]
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Electroporation-Based Treatments in Urology

The authors discuss the underlying mechanism of electroporation and an overview of the latest progress and development perspectives of electroporation-based treatments in urology.
[Cancers]
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The Role of Selenium Metabolism and Selenoproteins in Cartilage Homeostasis and Arthropathies

Scientists discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for osteoarthritis treatment.
[Experimental and Molecular Medicine]
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Understanding Paraxial Mesoderm Development and Sclerotome Specification for Skeletal Repair

The authors summarize the state-of-the-art understanding of mesoderm development and in vitro modeling of mesoderm development using PSCs. They also discuss future perspectives on the use of PSCs to generate skeletal tissues for basic research and clinical applications.
[Experimental and Molecular Medicine]
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The MMP14–Caveolin Axis and its Potential Relevance for Lipoedema

The authors suggest that lipoedema is an oestrogen-dependent disorder of adipose tissue, which is triggered by a dysfunction of caveolin 1 (CAV1) and subsequent uncoupling of feedback mechanisms between CAV1, the matrix metalloproteinase MMP14 and oestrogen receptors.
[Nature Reviews Endocrinology]
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Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Promotion of Tendon Repair – an Update of Literature

The author reviews the recent literature on the promotion of tendon repair using extracellular vesicles-derived from MSCs. The mechanisms underlying these actions are also reviewed and future research directions are discussed.
[Stem Cell Reviews and Reports]
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Modeling Oncogenic Herpesvirus Infections in Humanized Mice

The authors provide a brief introduction to the three most commonly utilized humanized mouse models for the study of gammaherpesvirus-driven pathogenesis.
[Current Opinion in Virology]
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Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

With the clinical trials and extensive basic research studying the biology of iPSCs, a promising future for human cell-based therapies using iPSCs seems to be increasingly clear and close.
[International Journal of Molecular Sciences]
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Application of Induced Pluripotent Stem Cells in Epilepsy

The authors provide an overview of iPSC lines that have been derived from patients with specific epilepsy types. They discuss the genetic underpinnings and molecular mechanisms of each epilepsy type.
[Molecular and Cellular Neuroscience]
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In Vitro Modeling for Inherited Neurological Diseases Using Induced Pluripotent Stem Cells: From 2D to Organoid

Researchers focus on stem cell-based in vitro modeling of neurodevelopmental disorders, more specifically, the fundamentals and technical advancements in monolayer neuron and brain organoid cultures.
[Archives of Pharmacal Research]
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Induced Pluripotent Stem Cells as a Platform to Understand Patient‐Specific Responses to Opioids and Anaesthetics

The authors examine the advantages and limitations of iPSC technology, summarize studies using iPSCs that have contributed to our current understanding of anaesthetics and opioid action on the cardiovascular and central nervous system, and describe how iPSC technology can be used to further develop personalized analgesic and sedative pharmacotherapies.
[British Journal of Pharmacology]
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