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Proteolysis Targeting Chimera (PROTAC) as a Promising Novel Therapeutic Modality for the Treatment of Triple-Negative Breast Cancer (TNBC)

[Drug Development Research] The authors give a brief overview of TNBC and PROTACs and highlight the rationale behind using PROTACs as a therapeutic modality in patients with TNBC.

Retinal Organoids from Human-Induced Pluripotent Stem Cells: from Studying Retinal Dystrophies to Early Diagnosis of Alzheimer’s and Parkinson’s Disease

[Seminars In Cell & Developmental Biology] The authors depict the possibility of evaluating changes related to both Alzheimer's and Parkinson’s disease in retinal organoids obtained from potential patients long before the onset of the disease, constituting a valuable tool in early diagnosis.

Approaches to Modeling Placental Function in Preeclampsia In Vitro and In Vivo

[Journal of Endocrinology] The authors review recent developments in stem-cell based models, organoids, and various co-culture systems which recapitulate various aspects of preeclampsia.

Injectable Hydrogels in Central Nervous System: Unique and Novel Platforms for Promoting Extracellular Matrix Remodeling and Tissue Engineering

[Materials Today Bio] Scientists discuss the pathophysiology of the central nervous system and the use of several kinds of injectable hydrogels for brain and spinal cord tissue engineering, paying particular emphasis to recent experimental studies.

Development of Substrates for the Culture of Human Pluripotent Stem Cells

[Biomaterials Science] The authors summarize the development of extracellular matrix proteins for hPSCs, which are now the mainstream alternative, and synthetic substrates that are expected to be the future mainstream alternative.

A Pluripotent Road to Immunoengineering

[Nature Reviews Bioengineering] The variability, time commitment, and cost of engineering chimeric antigen receptor-T cells limit their application. hPSCs could provide an off-the-shelf, cheaper, and scalable solution.

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