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Precision Medicine in Parkinson’s Disease Using Induced Pluripotent Stem Cells

[Advanced Healthcare Materials] Investigators introduce new model system of PD, including 2D human iPSC-derived midbrain dopaminergic neurons, 3D iPSC-derived midbrain organoids with cellular complexity, and more advanced microphysiological systems with 3D organoids.

Pneumocystis jirovecii Pneumonia in People Living with HIV: A Review

[Clinical Microbiology Reviews] The authors consolidate the scientific body of literature on the diagnosis and management of Pneumocystis jirovecii pneumonia in people with HIV, as well as identify areas in need of more study and thoughtfully designed clinical trials.

Idiopathic Pulmonary Fibrosis: From Common Microscopy to Single-Cell Biology and Precision Medicine

[American Journal Of Respiratory And Critical Care Medicine] The authors approach the fascinating historical evolution of knowledge about this disorder from the past century, until the current century, when the explosive progress in molecular genetics, epigenetics resulted in a huge advance in unveiling the pathogenic mechanisms of the disease.

Established and Emerging Biomarkers of Immunotherapy in Renal Cell Carcinoma

[Immunotherapy] The authors discuss biomarkers for immunotherapy in renal cell carcinoma (RCC), highlighting current practices and emerging innovations, aiming to contribute to improved outcomes for patients with RCC.

The Regulatory Role of CD36 in Hematopoiesis Beyond Fatty Acid Uptake

[Life Sciences] CD36 is a transmembrane glycoprotein, located on surface of numerous cell types. The authors aimed to explore regulatory role of CD36 in hematopoiesis beyond fatty acid uptake.

Current Status of Stem Cell Therapy for Type 1 Diabetes: A Critique and a Prospective Consideration

[Stem Cell Research & Therapy] Scientists identify the limitations that have to be overcome before stem cell therapy for diabetes becomes reliable and reproducible. As an alternative to cell therapy, the use of stem cell-derived extracellular vesicles is discussed as a future possibility.

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