Review

[Trends In Pharmacological Sciences] The authors outline the ex vivo manufacturing process as a motivating framework for direct in vivo strategies and discuss emerging data from preclinical models to highlight the potency of the in vivo approach

[Cancer And Metastasis Reviews] The utilization of genetically modified vectors enables in vivo production of CAR-T cells, thereby abbreviating or skipping the lengthy in vitro expansion process.

[Immunity] Myeloid C-type lectin receptors exhibited a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns, damage-associated molecular patterns, and markers of altered self.

[Trends In Molecular Medicine] Scientists review the impact of metabolic changes on the interplay among stromal, immune, and pancreatic tumor cells, as glutamine and branched-chain amino acids emerge as pivotal players in modulating immune cell functions and tumor growth.

[Ageing Research Reviews] Scientists illuminate the regulatory axes modulating signaling pathways in inflammatory cells by providing a comprehensive overview of the pathogenic processes associated with CCR5 and its ligands across various disorders.

[Clinical Gastroenterology And Hepatology] Metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis, has emerged as the most common chronic liver disease worldwide and a leading cause of HCC.