Investigators discuss how the role of NK cells evolves with tumor progression, presenting new opportunities to target NK cell function to enhance cancer immunotherapy response rates across a more diverse range of cancers.
[Nature Reviews Cancer]
Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology]
Granulocyte–macrophage colony-stimulating factor, a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials.
[Nature Reviews Immunology]
The authors highlight the current sources for natural killer (NK) therapies and their respective constraints, discuss recent developments in the manufacturing and genetic engineering of iPSC-NK cells, and provide an overview of ongoing clinical trials using NK cells.
[Stem Cell Research & Therapy]
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Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved June 23, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01741-4 Cite
The authors focus on the current studies of the MDM2–p53 axis in hepatocellular carcinoma, and specifically discuss the impact of MDM2–p53 axis dysfunction by viral infection and metabolic disease in the transformation of normal hepatocytes into hepatoma cells.
[Cell Death Discovery]
Investigators give an overview of T cell receptors identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field.
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The authors highlight the roles of kallikreins in skin homeostasis and pathologies. Due to their part in these skin disorders, inhibitors of the skin kallikreins have become attractive therapeutics.
[Critical Reviews in Clinical Laboratory Sciences]
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The role of kallikreins in inflammatory skin disorders and their potential as therapeutic targets: Critical Reviews in Clinical Laboratory Sciences: Vol 0, No 0. (n.d.). Retrieved June 24, 2020, from https://www.tandfonline.com/doi/abs/10.1080/10408363.2020.1775171?journalCode=ilab20 Cite
The authors review the molecular mechanism of insulin receptor endocytosis and its impact on the pathophysiology of insulin resistance, and discuss the potential of Src homology phosphatase 2 as a therapeutic target for type 2 diabetes.
[Experimental and Molecular Medicine]
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Main challenges to CAR-T cell therapy will be highlighted as well as strategies to structurally improve the CAR-T cell product, and thereby its efficacy and safety.
The authors summarize the roles and therapeutic potential of exosomes in osteoarthritis and discusses the perspectives and challenges related to exosome-based treatment for osteoarthritis patients in the future.
The authors examine aspects of Mixed Lineage Leukemia Translocated to, 10 (MLLT10), contextualizing its function in benign and malignant hematopoiesis.
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