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FOXO1, a Tiny Protein with Intricate Interactions: Promising Therapeutic Candidate in Lung Cancer

[Biomedicine & Pharmacotherapy] The authors focus on the signaling pathways, and molecular mechanisms involved in FOXO1 regulation in lung cancer, and discuss pharmacological compounds that are currently being administered for lung cancer treatment by affecting FOXO1.

Amino Acid-Stimulated Insulin Secretion: A Path Forward in Type 2 Diabetes

[Amino Acids] Investigators highlight evidence that supports the relative preservation of amino acid-stimulated insulin secretion compared to glucose-stimulated insulin secretion in type 2 diabetes, and make the case for the therapeutic potential of amino acids.

New Sights of Low Dose IL-2: Restoration of Immune Homeostasis for Viral Infection

[Immunology] The authors summarize the role of IL-2 or IL-2 complexes in viral infections as well as the application of ld-IL-2 in the context of autoimmune diseases combined with viral infections.

Epitranscriptomic Modifications in Mesenchymal Stem Cell Differentiation: Advances, Mechanistic Insights, and Beyond

[Cell Death & Differentiation] The authors highlight current challenges and potential future directions in the study of RNA modifications in MSCs, emphasizing the need for innovative tools to precisely map these modifications and decipher their context-specific effects.

How We Treat Sickle Cell Disease in Pregnancy

[Blood] Prior to and during pregnancy, in addition to the assessment and care that every pregnant patient should receive, patients with sickle cell disease should be evaluated and treated by a multidisciplinary team with respect to their unique maternal and fetal issues.

Human Fetal Tissue Is Critical for Biomedical Research

[Stem Cell Reports] The authors increased functionality of cells derived from fetal tissues arises from increased proliferative capacity, ability to survive in culture, and developmental potential that is attenuated in adult tissues.

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