Tumour Budding and Its Clinical Implications in Gastrointestinal Cancers

The authors give an update on International Tumour Budding Consensus Conference validation studies in the context of colorectal cancer and the clinical implications of tumour budding throughout the upper gastrointestinal and pancreatico-biliary tract.
[British Journal of Cancer]
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Advances in Immune Neoadjuvant/Adjuvant Therapy‐Related Adverse Events of Non‐Small Cell Lung Cancer

The authors discuss the role immunotherapy played in preoperative neoadjuvant and postoperative adjuvant treatment in lung cancer.
[Asia-Pacific Journal of Clinical Oncology]

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The Control of Conjunctival Fibrosis as a Paradigm for the Prevention of Ocular Fibrosis-Related Blindness. “Fibrosis Has Many Friends”

Scientists provide current and futures perspectives on different approaches to conjunctival fibrosis following glaucoma surgery and highlights the challenges faced in implementing these therapies with maximal effect and minimal side effects.
[Eye]
The control of conjunctival fibrosis as a paradigm for the prevention of ocular fibrosis-related blindness. “Fibrosis has many friends” | Eye. (n.d.). Retrieved July 2, 2020, from https://www.nature.com/articles/s41433-020-1031-9 Cite
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Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination

The authors review the latest literature describing the structure of the mammary gland and the breast cancer microenvironment (BCM) and summarize the influence of epithelial-mesenchymal transition and autophagy in breast cancer dissemination.
[Cancers]
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Embryonic Circulating Endothelial Progenitor Cells

The authors review in the literature concerning the features, origin and physiological functions of embryonic and fetal circulating endothelial progenitors.
[Angiogenesis]
Díaz del Moral, S., Barrena, S., Muñoz-Chápuli, R., & Carmona, R. (2020). Embryonic circulating endothelial progenitor cells. Angiogenesis. https://doi.org/10.1007/s10456-020-09732-y Cite
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Functional Loss of Pancreatic Islets in Type 2 Diabetes: How Can We Halt It?

The authors provide a view of the experimental and clinical evidence on the ability of available anti-diabetes drugs to exert protective effects on beta-cells, with a specific focus on human pancreatic islets and clinical trials.
[Metabolism-Clinical and Experimental]

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Extracellular Matrix Dynamics in Vascular Remodeling

The authors summarize how extracellular matrix (ECM) dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.
[American Journal of Physiology-Cell Physiology]
Extracellular Matrix Dynamics in Vascular Remodeling | American Journal of Physiology-Cell Physiology. (n.d.). Retrieved June 30, 2020, from https://journals.physiology.org/doi/abs/10.1152/ajpcell.00147.2020 Cite
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The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing

The authors review recent advances in the understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice.
[Annual Review of Cell and Developmental Biology]
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Gene and Stem Cell Therapies for Fetal Care: A Review

Fetal stem cell and gene therapy bring important therapeutic opportunities for select disorders that present in the fetal and neonatal periods. While this field is in its infancy, these therapies are starting to be available clinically, and clinicians should be aware of their benefits and challenges.
[JAMA Pediatrics]
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New Insights Into Molecular and Cellular Mechanisms of Zoledronate in Human Osteosarcoma

The authors provide the available literature on in vitro studies to illustrate the new insights into the intracellular molecular mechanisms of zoledronate in human osteosarcoma cell lines.
[Pharmacology & therapeutics]
Lu, K.-H., Lu, E. W.-H., Lin, C.-W., Yang, J.-S., & Yang, S.-F. (2020). New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma. Pharmacology & Therapeutics, 214, 107611. https://doi.org/10.1016/j.pharmthera.2020.107611 Cite
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Facts and Hopes in Immunotherapy of Soft Tissue Sarcomas

The authors focus on the role of the immune microenvironment in the development and activity of new therapeutic approaches, and the recent identification of the sarcoma immune class (SIC) groups, especially group SIC E with its B cell signature that predicts immunotherapy response.
[Clinical Cancer Research]
Martín-Broto, J., Moura, D. S., & Tine, B. A. V. (2020). Facts and hopes in immunotherapy of soft tissue sarcomas. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-19-3335 Cite
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