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The Role of NLRP1 Inflammasome in Skin Cancer and Inflammatory Skin Diseases

[British Journal Of Dermatology] The authors shed light on the implications of pathological dysregulation of the NLRP1 inflammasome in skin diseases and investigate the potential rationale for targeting this pathway as a future therapeutic approach.

T Cell Receptor Therapeutics: Immunological Targeting of the Intracellular Cancer Proteome

[Nature Reviews Drug Discovery] The authors discuss the unique complexities associated with the clinical development of these therapeutics, such as HLA restriction, T cell receptor retrieval, potency assessment, and the potential for cross-reactivity.

Hepatocellular Carcinoma: Up-Regulated Circular RNAs Which Mediate Efficacy in Preclinical In Vivo Models

[Cancer Genomics & Proteomics] Scientists provide an overview of up-regulated circular RNAs which mediate efficacy in preclinical in vivo models of HCC.

Inflammatory Signaling in NASH Driven by Hepatocyte Mitochondrial Dysfunctions

[Journal of Translational Medicine] The authors consider the role of impaired mitochondrial function caused by lipotoxicity during oxidative stress in hepatocytes.

Systematic Review: Predictive Value of Organoids in Colorectal Cancer

[Scientific Reports] The authors present a systematic review of studies that have tested the performance of patient-derived organoids to predict the effect of anti-cancer therapies in colorectal cancer, for chemotherapies, targeted drugs, and radiation therapy.

Therapeutic Biomarkers in Metastatic Castration-Resistant Prostate Cancer: Does the State Matter?

[Critical Reviews In Clinical Laboratory Sciences] Investigators outline precision medicine in metastatic cCRPC, zooming in on the role of circulating tumor DNA, to identify genomic biomarkers that may be used to tailor molecularly targeted therapies.

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