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Review
Dermal Cell News
The Role of NLRP1 Inflammasome in Skin Cancer and Inflammatory Skin Diseases
[British Journal Of Dermatology] The authors shed light on the implications of pathological dysregulation of the NLRP1 inflammasome in skin diseases and investigate the potential rationale for targeting this pathway as a future therapeutic approach.
Human Immunology News
T Cell Receptor Therapeutics: Immunological Targeting of the Intracellular Cancer Proteome
[Nature Reviews Drug Discovery] The authors discuss the unique complexities associated with the clinical development of these therapeutics, such as HLA restriction, T cell receptor retrieval, potency assessment, and the potential for cross-reactivity.
Hepatic Cell News
Hepatocellular Carcinoma: Up-Regulated Circular RNAs Which Mediate Efficacy in Preclinical In Vivo Models
[Cancer Genomics & Proteomics] Scientists provide an overview of up-regulated circular RNAs which mediate efficacy in preclinical in vivo models of HCC.
Hepatic Cell News
Inflammatory Signaling in NASH Driven by Hepatocyte Mitochondrial Dysfunctions
[Journal of Translational Medicine] The authors consider the role of impaired mitochondrial function caused by lipotoxicity during oxidative stress in hepatocytes.
Intestinal Cell News
Systematic Review: Predictive Value of Organoids in Colorectal Cancer
[Scientific Reports] The authors present a systematic review of studies that have tested the performance of patient-derived organoids to predict the effect of anti-cancer therapies in colorectal cancer, for chemotherapies, targeted drugs, and radiation therapy.
Cancer Stem Cell News
Therapeutic Biomarkers in Metastatic Castration-Resistant Prostate Cancer: Does the State Matter?
[Critical Reviews In Clinical Laboratory Sciences] Investigators outline precision medicine in metastatic cCRPC, zooming in on the role of circulating tumor DNA, to identify genomic biomarkers that may be used to tailor molecularly targeted therapies.