Review

[ACS Materials Au] The authors provide an overview of the design, preparation, methodology, and oncological aspects of organic polymeric nanoparticles-based photodynamic therapy for the treatment of prostate cancer.

[Journal Of Hepatology] One of the most striking features of PSC is its association with inflammatory bowel disease (IBD), with the majority of patients with PSC being diagnosed with extensive colitis. The authors describesthe epidemiology of IBD in PSC, its specific phenotype, complications and potential pathophysiological mechanisms connecting the two diseases.

[Molecular Neurodegeneration] Scientists cover the current understanding of the molecular mechanisms of cyclic GMP-AMP synthase (cGAS) activation and highlight cGAS-stimulator of interferon genes (STING) signaling in various cell types of central and peripheral nervous systems, such as resident brain immune cells, neurons, and glial cells.

[Molecular Neurodegeneration] The authors describe and summarize the current efforts made in the development of peptides and their mimetics to directly engage with alpha-synuclein with the intention of modulating aggregation, and importantly, toxicity.

[Neuron] Investigators summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology.

[Skeletal Muscle] The authors consolidate over three decades of research about the role of TPM3 in skeletal muscle. Overall, the progress made has led to a better understanding of the phenotypic spectrum in patients affected by mutations in this gene.