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ulcerative colitis

Single-Cell RNA Sequencing Reveals Induction of Distinct Trained Immunity Programs in Human Monocytes

[Journal of Clinical Investigation] Researchers demonstrated cellular transcriptional programs to four different inducers of trained immunity in monocyte populations at single-cell resolution.

Loss of NFE2L3 Protects against Inflammation-Induced Colorectal Cancer through Modulation of the Tumor Microenvironment

[Oncogene] Researchers investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer.

Mesenchymal Stromal Cells Encapsulated in Licensing Hydrogels Exert Delocalized Systemic Protection against Ulcerative Colitis via Subcutaneous Xenotransplantation

[European Journal of Pharmaceutics and Biopharmaceutics] Researchers demonstrated the capacity of licensing hydrogel-encapsulated human MSCs to limit the in vivo progression of inflammatory bowel diseases.

Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases

[Advanced Materials] IFN-γ treatment induced remarkable PD-L1 expression on PD-L1-expressing macrophage membrane (PRM), thereby allowing PRM nanodecoys to bind mPD-1 on CD4+ T cell surfaces or neutralize free sPD-1, which reconstructed the PD-1/PD-L1 inhibitory axis to suppress CD4+ T cell activation and restore immune tolerance.

Takeda Receives Positive CHMP Opinion for Vedolizumab IV for the Treatment of Active Chronic Pouchitis

[Takeda Pharmaceutical Company Limited] Takeda Pharmaceutical Company Limited announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended the approval of intravenous vedolizumab for the treatment of adult patients with moderately to severely active chronic pouchitis.

MUC2 and Related Bacterial Factors: Therapeutic Targets for Ulcerative Colitis

[Ebiomedicine] Bacterial factors related to the mucin2 (MUC2) mucus barrier play important roles in the response to changes in dietary patterns, MUC2 mucus barrier dysfunction, contact stimulation with colonic epithelial cells, and mucosal and submucosal inflammation during the occurrence and development of ulcerative colitis.

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