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ulcerative colitis

H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

[Disease Markers] Scientists treated ulcerative colitis animals with MSC preconditioned with or without H19 and compared the therapeutic effect of MSC and MSC-H19.

CCL11 Exacerbates Colitis and Inflammation-Associated Colon Tumorigenesis

[Oncogene] Scientists showed that CCL11 was involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis and in colon tumorigenesis in the azoxymethane-DSS model of colitis-associated carcinogenesis.

TLR4 Signaling in the Development of Colitis-Associated Cancer and Its Possible Interplay with microRNA-155

[Cell Communication and Signaling] Considerable attention has been focused on the regulation of TLR4 signaling in the context of colitis-associated tumorigenesis. MicroRNA-155 and TLR4 exhibited a similar dynamic expression change during colitis-associated cancer (CAC) development and shared similar CAC-promoting properties.

Deoxycholic Acid Delays the Wound Healing of Colonic Epithelial Cells via Transmembrane G-Protein-Coupled Receptor 5

[Journal of Gastroenterology and Hepatology] Researchers investigated the role of transmembrane G-protein-coupled receptor in wound healing in the context of colonic epithelial cells in the presence of bile acids.

Bile Acid Signaling in Inflammatory Bowel Disease

[International Journal of Molecular Sciences] The authors summarize recent advances in the field of bile acid signaling, studies of inflamed gut microbiome, and the therapeutic potential of bile acids in the context of inflammatory bowel disease.

Estrogen Receptor Actions in Colitis

[Essays in Biochemistry] Investigators provide an overview of estrogen and its receptors, particularly ERβ, in the pathophysiology of IBDs.

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