β3-Endonexin Interacts with Ninein in Vascular Endothelial Cells to Promote Angiogenesis

Scientists utilized a β3-endonexin mutant carrying a defective nuclear localization sequence to disrupt its nuclear localization and evaluated its ability to promote HUVEC proliferation and formation of tube-like vascular structures.
[Biochemical and Biophysical Research Communications]
Cao, Z., Ge, S., Xu, Z., & Ma, Y.-Q. (2021). β3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis. Biochemical and Biophysical Research Communications, 566, 75–79. https://doi.org/10.1016/j.bbrc.2021.06.008 Cite
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Targeting the SHP2 Phosphatase Promotes Vascular Damage and Inhibition of Tumor Growth

The authors reported that SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.
[EMBO Molecular Medicine]
Wang, Y., Salvucci, O., Ohnuki, H., Tran, A. D., Ha, T., Feng, J.-X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., & Tosato, G. (2021). Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth. EMBO Molecular Medicine, n/a(n/a), e14089. https://doi.org/10.15252/emmm.202114089 Cite
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Cannabinoids Orchestrate Cross-Talk between Cancer Cells and Endothelial Cells in Colorectal Cancer

RNA-sequencing datasets in the NCBI GEO repository were first analyzed; upregulation of cannabinoid receptors was observed in both primary and metastatic colorectal cancer tumor tissues.
[Cancer Gene Therapy]
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Fibroblast CEBPD/SDF4 Axis in Response to Chemotherapy-Induced Angiogenesis through CXCR4

The authors found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein delta and consequently promote proliferation, migration, and in vitro tube formation of vascular endothelial cells and angiogenesis in vivo.
[Cell Death & Discovery]
Chi, J.-Y., Hsiao, Y.-W., Liu, H.-L., Fan, X.-J., Wan, X.-B., Liu, T.-L., Hung, S.-J., Chen, Y.-T., Liang, H.-Y., & Wang, J.-M. (2021). Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4. Cell Death Discovery, 7(1), 1–16. https://doi.org/10.1038/s41420-021-00478-0 Cite
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A Novel Strategy for Isolation of Mice Bone Marrow Endothelial Cells (BMECs)

Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]
Smith, A. O., Adzraku, S. Y., Ju, W., Qiao, J., Xu, K., & Zeng, L. (2021). A novel strategy for isolation of mice bone marrow endothelial cells (BMECs). Stem Cell Research & Therapy, 12(1), 267. https://doi.org/10.1186/s13287-021-02352-3 Cite
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Hyperoxia-Activated Circulating Extracellular Vesicles Induce Lung and Brain Injury in Neonatal Rats

Investigators utilized a neonatal rat model of bronchopulmonary dysplasia to assess if hyperoxia stimulates lung release of circulating extracellular vesicles(EVs) and if these EVs induce lung and brain injury.
[Scientific Reports]
Ali, A., Zambrano, R., Duncan, M. R., Chen, S., Luo, S., Yuan, H., Chen, P., Benny, M., Schmidt, A., Young, K., Kerr, N., de Rivero Vaccari, J. P., Keane, R. W., Dietrich, W. D., & Wu, S. (2021). Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats. Scientific Reports, 11(1), 8791. https://doi.org/10.1038/s41598-021-87706-w Cite
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Paracrine Interleukin-8 Affects Mesenchymal Stem Cells through the Akt Pathway and Enhances Human Umbilical Vein Endothelial Cell Proliferation and Migration

Cultured human umbilical vein endothelial cells (HUVECs) were cultured in bone marrow mesenchymal stem cell conditioned medium
[Bioscience Reports]
wang, L., Li, Y., Zhang, X., Liu, N., Shen, S., Sun, S., Jiang, Y., Li, P., Jin, H., & Shen, L. (2021). Paracrine Interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration. Bioscience Reports, BSR20210198. https://doi.org/10.1042/BSR20210198 Cite
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First Blood: The Endothelial Origins of Hematopoietic Progenitors

Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
[Angiogenesis]
Canu, G., & Ruhrberg, C. (2021). First blood: the endothelial origins of hematopoietic progenitors. Angiogenesis. https://doi.org/10.1007/s10456-021-09783-9 Cite
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The CREB/KMT5A Complex Regulates PTP1B to Modulate High Glucose-Induced Endothelial Inflammatory Factor Levels in Diabetic Nephropathy

The authors hypothesized that cAMP response element-binding protein (CREB) associated with KMT5A to modulate PTP1B expression, thus contributing to high glucose-mediated glomerular endothelial inflammation.
[Cell Death & Disease]
Huang, T., Li, X., Wang, F., Lu, L., Hou, W., Zhu, M., & Miao, C. (2021). The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03629-4 Cite
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Regional Specification and Complementation with Non-neuroectodermal Cells in Human Brain Organoids

The authors highlight recent advances of neuronal organoid technologies, focusing on the region-specific brain organoids and complementation with endothelial cells and microglia
[Journal of Molecular Medicine]
Tanaka, Y., & Park, I.-H. (2021). Regional specification and complementation with non-neuroectodermal cells in human brain organoids. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-021-02051-9 Cite
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