miR-34a interacted with SIRT1 and suppressed SIRT1 expression. MiR-34a overexpression inhibited proliferation and promoted apoptosis of rat retinal vascular endothelial cells, which was effectively abolished by SIRT1 up-regulation.
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Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.
[International Journal of Molecular Sciences]
Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
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You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
When GCSDL contacted with tumor vascular endothelial cells, the overexpressed γ‐glutamyltranspeptidase enzyme on cytomembrane catalyzed the hydrolysis of GSH to generate cationic primary amines.
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Tim-3 was overexpressed in vascular endothelial HMVECs and HUVECs and in vitro assays were used to determine that Tim-3 promoted cell proliferation, migration, invasion and tube formation through activating cyclin D1, Ras homolog gene family member A and vascular endothelial growth factor receptor 2.
The authors’ in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells.
[Experimental and Molecular Medicine]
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Shen, X., Chen, X., Wang, J., Liu, J., Wang, Z., Hua, Q., Wu, Q., Su, Y., He, H., Hu, Y., Meng, Z., Xiong, W., & Zhu, M. (2020). SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-00509-3 Cite
The authors generated induced vascular endothelial cells and smooth muscle cells by direct reprogramming of healthy human fibroblasts from donors of different ages and Hutchinson-Gilford Progeria Syndrome patients.
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With age, expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) was increased in the pulmonary alveolar epithelial barrier, cardiomyocytes, and vascular endothelial cells.
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Ma, S., Sun, S., Li, J., Fan, Y., Qu, J., Sun, L., Wang, S., Zhang, Y., Yang, S., Liu, Z., Wu, Z., Zhang, S., Wang, Q., Zheng, A., Duo, S., Yu, Y., Belmonte, J. C. I., Chan, P., Zhou, Q., … Liu, G.-H. (2020). Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Research, 1–18. https://doi.org/10.1038/s41422-020-00412-6 Cite
Researchers demonstrated that ‘reset’ vascular endothelial cells established an adaptive vascular niche that differentially adjusted and conformed to organoids and tumoroids in a tissue-specific manner.
Using single-cell RNA sequencing and epigenetic profiling, scientists demonstrated that ‘reset’ vascular endothelial cells established an adaptive vascular niche that differentially adjusted and conformed to organoids and tumoroids in a tissue-specific manner.
ApoC1 in the exosomes were transferred from the clear cell renal cell carcinoma cells (ccRCC) to the vascular endothelial cells and promoted metastasis of the ccRCC via activating STAT3.