Scientists utilized a β3-endonexin mutant carrying a defective nuclear localization sequence to disrupt its nuclear localization and evaluated its ability to promote HUVEC proliferation and formation of tube-like vascular structures.
[Biochemical and Biophysical Research Communications]
The authors reported that SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.
[EMBO Molecular Medicine]
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Wang, Y., Salvucci, O., Ohnuki, H., Tran, A. D., Ha, T., Feng, J.-X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., & Tosato, G. (2021). Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth. EMBO Molecular Medicine, n/a(n/a), e14089. https://doi.org/10.15252/emmm.202114089 Cite
RNA-sequencing datasets in the NCBI GEO repository were first analyzed; upregulation of cannabinoid receptors was observed in both primary and metastatic colorectal cancer tumor tissues.
[Cancer Gene Therapy]
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The authors found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein delta and consequently promote proliferation, migration, and in vitro tube formation of vascular endothelial cells and angiogenesis in vivo.
[Cell Death & Discovery]
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Chi, J.-Y., Hsiao, Y.-W., Liu, H.-L., Fan, X.-J., Wan, X.-B., Liu, T.-L., Hung, S.-J., Chen, Y.-T., Liang, H.-Y., & Wang, J.-M. (2021). Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4. Cell Death Discovery, 7(1), 1–16. https://doi.org/10.1038/s41420-021-00478-0 Cite
Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]
Investigators utilized a neonatal rat model of bronchopulmonary dysplasia to assess if hyperoxia stimulates lung release of circulating extracellular vesicles(EVs) and if these EVs induce lung and brain injury.
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Ali, A., Zambrano, R., Duncan, M. R., Chen, S., Luo, S., Yuan, H., Chen, P., Benny, M., Schmidt, A., Young, K., Kerr, N., de Rivero Vaccari, J. P., Keane, R. W., Dietrich, W. D., & Wu, S. (2021). Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats. Scientific Reports, 11(1), 8791. https://doi.org/10.1038/s41598-021-87706-w Cite
Cultured human umbilical vein endothelial cells (HUVECs) were cultured in bone marrow mesenchymal stem cell conditioned medium
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wang, L., Li, Y., Zhang, X., Liu, N., Shen, S., Sun, S., Jiang, Y., Li, P., Jin, H., & Shen, L. (2021). Paracrine Interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration. Bioscience Reports, BSR20210198. https://doi.org/10.1042/BSR20210198 Cite
Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
The authors hypothesized that cAMP response element-binding protein (CREB) associated with KMT5A to modulate PTP1B expression, thus contributing to high glucose-mediated glomerular endothelial inflammation.
[Cell Death & Disease]
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ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
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Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
The authors highlight recent advances of neuronal organoid technologies, focusing on the region-specific brain organoids and complementation with endothelial cells and microglia
[Journal of Molecular Medicine]