Vitexin Inhibits APEX1 to Counteract the Flow-Induced Endothelial Inflammation

The authors demonstrated that vitexin, a natural flavonoid, could inhibit the activation of apurinic/apyrimidinic endonuclease1 (APEX1) to protect vascular endothelium against the adverse effects of atherogenic stimuli.
[Proceedings of the National Academy of Sciences of the United States of America]
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Lymph Node Formation and B Cell Homeostasis Require IKK-α in Distinct Endothelial Cell–Derived Compartments

Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Mitophagy Mediates Metabolic Reprogramming of Induced Pluripotent Stem Cells Undergoing Endothelial Differentiation

To evaluate mitophagy during iPSC differentiation, investigators performed live cell imaging of mitochondria and lysosomes in human iPSCs differentiating into vascular endothelial cells using confocal microscopy.
[Journal of Biological Chemistry]
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CD5L Deficiency Attenuate Acetaminophen-Induced Liver Damage in Mice via Regulation of Jnk and Erk Signaling Pathway

The authors found that the expression of CD5 molecule like (CD5L) was increased in the livers of mice after acetaminophen (APAP) overdose, revealing that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury.
[Cell Death Discovery]
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Fraxinellone Ameliorates Intracerebral Hemorrhage-Induced Secondary Brain Injury by Regulating Krüppel-Like Transcription Factor 2 Expression in Rats

An intracerebral hemorrhage (ICH) model was established by injecting autologous blood into the right basal ganglia of Sprague-Dawley rats. After ICH induction, the protein levels of Krüppel-like transcription factor 2 were reduced.
[Brain Research Bulletin]
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Terns Completes Part 1 Enrollment of AVIATION Phase Ib NASH Clinical Trial of VAP-1 Inhibitor TERN-201

Terns Pharmaceuticals, Inc. announced the completion of patient enrollment of Part 1 of the AVIATION Trial, a Phase Ib clinical trial evaluating TERN-201, an orally-administered, highly selective inhibitor of vascular adhesion protein-1 (VAP-1), in patients with non-alcoholic steatohepatitis (NASH).
[Terns Pharmaceuticals, Inc. (GlobeNewswire, Inc.)]
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Fibronectin‐Mediated Inflammatory Signaling through Integrin α5 in Vascular Remodeling

Investigators examined mice in which integrin α5 was replaced with the α5/2 chimera, using the transverse aortic constriction and partial carotid ligation models of vessel remodeling.
[Journal of the American Heart Association]
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C1q/Tumor Necrosis Factor-Related Protein-3 Improves Microvascular Endothelial Function in Diabetes through the AMPK/eNOS/NO· Signaling Pathway

Investigators demonstrated that the C1q-like globular domain of C1q/tumor necrosis factor-related protein (CTRP)3, CTRP5, and CTRP9 exerted a vasorelaxant effect on the microvasculature, of which gCTRP3 was the most powerful one.
[Biochemical Pharmacology]
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MiR-20b-5p Modulates Inflammation, Apoptosis and Angiogenesis in Severe Acute Pancreatitis through Autophagy by Targeting AKT3

Cerulean and LPS was used to establish a rat model and an in vitro model of severe acute pancreatitis. qRT-PCR, western blot and IHC were determined to analyse the expression of mRNA and proteins. IL-1β, TNF-α and IL-6 levels were measured applying ELISA.
[Autoimmunity]
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Maternal Supply of Cysteamine Alleviates Oxidative Stress and Enhances Angiogenesis in Porcine Placenta

Researchers investigated the potential of cysteamine as an antioxidant protectant for regulating the reproductive performance, redox status, and placental angiogenesis of sows.
[Journal of Animal Science and Biotechnology]
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The COL-4A1 Polypeptide Destroy Endothelial Cells through the TGF-β/PI3K/AKT Pathway

Human umbilical vascular endothelial cells were cultured with or without COL-4A1 and TNF-α. Cell Counting Kit-8, wound-healing, Transwell and tube formation assays were used to evaluate cell proliferation, migration and angiopoiesis.
[Scientific Reports]
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