The authors investigated changes of the vascular smooth muscle cell (VSMC) transcriptome by utilizing 3D human vascular organoids organized as a core of VSMCs enclosed by a monolayer of endothelial cells.
[Experimental Cell Research]
1254621 9MKKK5G7 items 1 apa default asc 1
The authors outline the role of LOX-1 in tumor spreading and metastasis, evidencing its function in VEGF induction, HIF-1alpha activation, and MMP-9/MMP-2 expression, pushing up the neoangiogenic and the epithelial-mesenchymal transition process in glioblastoma, osteosarcoma, prostate, colon, breast, lung, and pancreatic tumors.
[Cancer Gene Therapy]
The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
[International Journal of Hematology]
1254621 PKM32W8W items 1 apa default asc 1
Human umbilical vein endothelial cells (HUVECs) were used to replicate the aging model, and the population doubling levels during cell passage were counted. Senescence-associated β-galactosidase staining, real-time quantitative PCR, MTT assay, Transwell, and tube formation were used to detect the effects of miR-217 on young and senescent HUVECs.
[Journal of Molecular Histology]
1254621 Y7AGK9FJ items 1 apa default asc 1
The ability of GSK2798745 to block TRPV4 agonist GSK1016790-induced impendence reduction in human umbilical vein endothelial cells in the presence of human whole blood was assessed.
[Journal of Pharmacology and Experimental Therapeutics]
1254621 HH57CK6L items 1 apa default asc 1
Investigators HMPL-013 inhibited VEGF/VEGFR2 binding in choroidal endothelial cells and macrophages, as well as macrophage M1 polarization. In vitro, noncontact coculture of human choroidal vascular endothelial cells and macrophages under hypoxia conditions was established.
[Cell Death & Disease]
6445212 3NY5NPV3 items 1 apa default asc 1
Liu, X., Guo, A., Tu, Y., Li, W., Li, L., Liu, W., Ju, Y., Zhou, Y., Sang, A., & Zhu, M. (2020). Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization. Cell Death & Disease, 11(11), 1–13. https://doi.org/10.1038/s41419-020-03222-1 Cite
VEGF-induced endothelial cell (EC) migration was diminished in Yin Yang 1 (YY1)-depleted HUVECs. A rescue experiment revealed that YY1-regulated BMP6 expression in ECs was involved in EC migration.
Researchers explored the pathogenesis of diabetic retinopathand identified new treatments that can provide dual-target intervention for angiogenesis and fibrosis. They explored changes in gene expression in high glucose–induced vascular endothelial cells using RNA sequencing technology.
[International Journal of Molecular Medicine]
Human umbilical cord MSCs (hucMSCs) and human umbilical vein endothelial cells (HUVECs) were isolated from human umbilical cords and characterized by a series of experiments. Lentivirus vector encoding miRNA-126-3p was transfected into hucMSCs and verified by PCR.
[Stem Cell Research & Therapy]
6445212 TQ4LQXDN items 1 apa default asc 1
Qu, Q., Wang, L., Bing, W., Bi, Y., Zhang, C., Jing, X., & Liu, L. (2020). miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo. Stem Cell Research & Therapy, 11(1), 464. https://doi.org/10.1186/s13287-020-01978-z Cite
The glycolysis index, including glucose uptake, ATP and lactate production stayed at a relatively high level in human dermal lymphatic endothelial cells (HDLECs) compared with HUVECS, while inhibition of PKM2 by shikinon or PKM2 knockdown could significantly suppress glycolysis, migration, tubular formation, and invasion of HDLECs.
[American Journal of Pathology]
6445212 69PMHCMG items 1 apa default asc 1
Jiang, H., Zou, Y., Zhao, J., Li, X., Yang, S., Zhou, X., Mou, D., Zhong, W., & Cai, Y. (2020). Pyruvate kinase M2 mediates the glycolysis in the lymphatic endothelial cells and its potential relation to the progression of lymphatic malformations. The American Journal of Pathology, 0(0). https://doi.org/10.1016/j.ajpath.2020.10.003 Cite
Fibroblast growth factor (FGF) 2, also called basic FGF, had the potential to accelerate wound closure by activating vascular endothelial cells and fibroblasts. Scientists examined the effects of FGF2 on keratinocyte morphology and epithelial–mesenchymal transition in wounded skin.
6807162 VW55Q7MV items 1 apa default asc 1