vascular endothelial cells

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that vitexin, a natural flavonoid, could inhibit the activation of apurinic/apyrimidinic endonuclease1 (APEX1) to protect vascular endothelium against the adverse effects of atherogenic stimuli.

[Journal of Biological Chemistry] To evaluate mitophagy during iPSC differentiation, investigators performed live cell imaging of mitochondria and lysosomes in human iPSCs differentiating into vascular endothelial cells using confocal microscopy.

[Cell Death Discovery] The authors found that the expression of CD5 molecule like (CD5L) was increased in the livers of mice after acetaminophen (APAP) overdose, revealing that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury.

[Brain Research Bulletin] An intracerebral hemorrhage (ICH) model was established by injecting autologous blood into the right basal ganglia of Sprague-Dawley rats. After ICH induction, the protein levels of Krüppel-like transcription factor 2 were reduced.

[Terns Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] Terns Pharmaceuticals, Inc. announced the completion of patient enrollment of Part 1 of the AVIATION Trial, a Phase Ib clinical trial evaluating TERN-201, an orally-administered, highly selective inhibitor of vascular adhesion protein-1 (VAP-1), in patients with non-alcoholic steatohepatitis (NASH).

[Journal of the American Heart Association] Investigators examined mice in which integrin α5 was replaced with the α5/2 chimera, using the transverse aortic constriction and partial carotid ligation models of vessel remodeling.