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western blot analysis

LncRNA UCA1 Promotes SOX12 Expression in Breast Cancer by Regulating m6A Modification of miR-375 by METTL14 through DNA Methylation

[Cancer Gene Therapy] Researchers elucidated the underlying mechanism by which lncRNA UCA1 affected the m6A modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer.

Caveolin-1 Alleviates Crohn’s Disease–Induced Intestinal Fibrosis by Inhibiting Fibroblasts Autophagy through Modulating Sequestosome 1

[Inflammatory Bowel Diseases] Human Crohn's disease (CD) tissue samples were gained from patients with CD who underwent surgical resection of the intestine and were defined as stenotic or nonstenotic areas.

Overexpression of miR-375 Reverses the Effects of Dexamethasone on the Viability, Migration, Invasion and Apoptosis of Human Airway Epithelial Cells by Targeting DUSP6

[International Journal of Molecular Medicine] The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.

MicroRNA-149 Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells via Inhibition of AKT1-Dependent Twist1 Phosphorylation

[Cell Death Discovery] Scientists elucidated the role of miR-149 in osteogenic differentiation of MSCs and the underlying mechanism.

Endothelial Cells Are an Important Source of BDNF in Rat Skeletal Muscle

[Scientific Reports] Scientists provided a comprehensive analysis of BDNF localization in rat skeletal muscle.

STAT3 as a Target for Sensitizing Prostate Cancer Cells to Irradiation

[Radiation Research] Investigators demonstrated that STAT3 blockade with a STAT3 inhibitor or siRNA increased the radiosensitivity of prostate cancer (PCa) cells and that radiation together with STAT3 blockade induced more apoptosis and double-strand breaks than radiation alone in LNCaP cells.

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