Wnt/β-catenin

[Cell Death & Disease] Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.

[Acta Biomaterialia] Researchers determined that M2-Exos could augment the angiogenic activities of spinal cord microvascular endothelial cells in vitro.

[Cell Death Discovery] Findings demonstrated that DLGAP1-AS2 was significantly up-regulated in gastric cancer (GC) and its high expression was associated with poor prognosis, suggesting that DLGAP1-AS2 might be a putative oncogenic lncRNA of GC. Loss of DLGAP1-AS2 restricted cell proliferation, migration, and invasion in GC cell lines.

[Gastroenterology] The authors generated Strap intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.

[Kaohsiung Journal of Medical Sciences] The regulatory role of miR-19b in colorectal cancer stem cells and radiotherapy-resistant cells was determined using miRNA microarray analysis, and its prognostic value was probed using the TCGA database.

[Scientific Reports] The authors demonstrated that entricular tachycardias susceptibility in the chronic phase after myocardial infarction was reduced in mice with cardiomyocyte-specific β-catenin deletion primarily through attenuated structural remodeling, but not ion channel gene alterations.