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Wnt/β-catenin

β-Catenin Perturbations Control Differentiation Programs in Mouse Embryonic Stem Cells

[iScience] By applying an in vitro system enabling inducible gene expression control, investigators reported that moderate induction of transcriptionally active exogenous β-catenin in β-catenin null mouse ESCs promoted epiblast-like cell derivation in vitro.

Fibrinogen Improves Liver Function via Promoting Cell Aggregation and Fibronectin Assembly in Hepatic Spheroids

[Biomaterials] Human primary hepatocyte organoids and HepaRG spheroids showed more mature hepatocyte phenotype after adding fibronectin and fibrinogen to the culture system.

Downregulation of SFRP2 Facilitates Cancer Stemness and Radioresistance of Glioma Cells via Activating Wnt/β-Catenin Signaling

[PLoS One] Researchers found that secreted frizzled-related protein 2 (SFRP2) was downregulated in radiotherapy-treated glioma patients, and low SFRP2 expression was correlated with advanced tumor stage and poor prognosis.

TAZ Exhibits Phase Separation Properties and Interacts with Smad7 and β-Catenin to Repress Skeletal Myogenesis

[Journal of Cell Science] Researchers assessed a potential role of TAZ on theSmad7/β-catenin complex in muscle cells. They documented functional interactions between Smad7, TAZ and β-catenin in myogenic cells.

Loss of DSTYK Activates Wnt/β-Catenin Signaling and Glycolysis in Lung Adenocarcinoma

[Cell Death & Disease] Researchers showed that the loss of dual serine/threonine tyrosine protein kinase led to the activation of Wnt/β-catenin signaling and upregulation of its target gene, lactate dehydrogenase, and thus the elevation of lactate.

Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance

[Gynecological Oncology] Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence

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