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Wnt/β-catenin

HIF-1–Regulated Expression of Calreticulin Promotes Breast Tumorigenesis and Progression through Wnt/β-Catenin Pathway Activation

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.

Natriuretic Peptides Are Neuroprotective on In Vitro Models of PD and Promote Dopaminergic Differentiation of hiPSCs-Derived Neurons via the Wnt/β-Catenin Signaling

[Cell Death Discovery] Scientists reported that atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide accelerated the dopaminergic differentiation of human induced pluripotent stem cells (hiPSCs)-derived neural population, making these attractive molecules for both neuroprotection and neurorepair in Parkinson’s disease (PD).

Exosomes from Bone Marrow Mesenchymal Stem Cells Promoted Osteogenic Differentiation by Delivering miR-196a That Targeted Dickkopf-1 to Activate Wnt/β-Catenin Pathway

[Bioengineered] Researchers demonstrated that exosomes extracted from bone marrow MSCs (BMSC-exo) significantly promoted HFOB1.19 differentiation to osteoblasts, and found that BMSC-exo were enriched with miR-196a and delivered miR-196a to HFOB1.19 cells to inhibit its target Dkk1, which was a negative regulator of Wnt/β-catenin pathway.

Histone Deacetylase 6-Mediated Downregulation of TMEM100 Expedites the Development and Progression of Non-Small Cell Lung Cancer

[Human Cell] Researchers elucidated the role of histone deacetylase 6 in regulating epithelial-mesenchymal transition-mediated metastasis via mRNA in NSCLC.

Pseudevernia furfuracea Inhibits Migration and Invasion of Colorectal Carcinoma Cell Lines

[Journal of Ethnopharmacology] Researchers showed antimigratory/invasive potential of Pseudevernia furfuracea methanol extract on HCT-116 and SW-480 colorectal carcinoma cell lines and elucidated possible mechanism of its action.

CPT2 Downregulation Triggers Stemness and Oxaliplatin Resistance in Colorectal Cancer via Activating the ROS/Wnt/β-Catenin-Induced Glycolytic Metabolism

[Experimental Cell Research] Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.

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