xenograft models

[Cell Death Discovery] Researchers performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in NSCLC cells.

[Cell Death Discovery] Scientists analyzed the regulatory relationship of hypoxia and PVT1 and the mechanism of PVT1 in the hypoxia-induced chemoresistance process of lung cancer.

[Cell Death Discovery] The authors investigated the expression pattern, clinical prognosis, tumor biological functions, and molecular mechanisms of WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in intrahepatic cholangiocarcinoma.

[Radiotherapy and Oncology] The authors investigated the effect of a novel oxygen-generating polymer-lipid manganese dioxide nanoparticle on improving radiation therapy (RT) outcomes in CRPC xenograft models by modulating the tumor microenvironment both before and after RT.

[Oncogene] Researchers identified a 21-amino-acid survival-associated micropeptide XBP1SBM, encoded by the long non-coding RNA (lncRNA) MLLT4-AS1, which was upregulated in TNBC tissues and glutamine-deprived TNBC cell lines.

[Nature Biomedical Engineering] Scientists showed that functional CAR T cells could be generated within 24 hours from T cells derived from peripheral blood without the need for T cell activation or ex vivo expansion.