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xenograft models
Pulmonary Cell News
Claudin1 Decrease Induced by 1,25-Dihydroxy-Vitamin D3 Potentiates Gefitinib Resistance Therapy through Inhibiting AKT Activation-Mediated Cancer Stem-Like Properties in NSCLC Cells
[Cell Death Discovery] Researchers performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in NSCLC cells.
Pulmonary Cell News
Hypoxia-Induced PVT1 Promotes Lung Cancer Chemoresistance to Cisplatin by Autophagy via PVT1/miR-140-3p/ATG5 Axis
[Cell Death Discovery] Scientists analyzed the regulatory relationship of hypoxia and PVT1 and the mechanism of PVT1 in the hypoxia-induced chemoresistance process of lung cancer.
Hepatic Cell News
WWP1 Upregulation Predicts Poor Prognosis and Promotes Tumor Progression by Regulating Ubiquitination of NDFIP1 in Intrahepatic Cholangiocarcinoma
[Cell Death Discovery] The authors investigated the expression pattern, clinical prognosis, tumor biological functions, and molecular mechanisms of WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in intrahepatic cholangiocarcinoma.
Prostate Cell News
Redox-Responsive Nanoparticles Enhance Radiation Therapy by Altering Multifaceted Radio-Resistance Mechanisms in Human Castration-Resistant Prostate Cancer Cells and Xenografts
[Radiotherapy and Oncology] The authors investigated the effect of a novel oxygen-generating polymer-lipid manganese dioxide nanoparticle on improving radiation therapy (RT) outcomes in CRPC xenograft models by modulating the tumor microenvironment both before and after RT.
Mammary Cell News
A Micropeptide XBP1SBM Encoded by lncRNA Promotes Angiogenesis and Metastasis of TNBC via XBP1s Pathway
[Oncogene] Researchers identified a 21-amino-acid survival-associated micropeptide XBP1SBM, encoded by the long non-coding RNA (lncRNA) MLLT4-AS1, which was upregulated in TNBC tissues and glutamine-deprived TNBC cell lines.
Cell Therapy News
Rapid Manufacturing of Non-Activated Potent CAR T Cells
[Nature Biomedical Engineering] Scientists showed that functional CAR T cells could be generated within 24 hours from T cells derived from peripheral blood without the need for T cell activation or ex vivo expansion.