xenograft models

[Scientific Reports] Investigators demonstrated that Neuropeptide Y Receptor Y1 (NPY1R) mediated the inhibitory action of NPY on estradiol-stimulated growth of ER+ breast cancer (BC) cells, and its expression served as a biomarker to predict endocrine sensitivity and survival in ER+ BC patients.

[Nature Communications] By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of lung adenocarcinoma and squamous cell carcinoma, scientists found that ∆Np63 promoted NSCLC by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence.

[Molecular Cancer Research] Integrated copy number aberration and gene expression analysis of primary high-risk prostate cancer identified the AZIN1 gene as a novel driver of metastatic progression, by altering collagen subunit expression.

[Cellular Oncology] Scientists showed that the expression of DDR1 was significantly increased in HCC and was related to a poor clinical prognosis.

[Molecular Therapy-Oncolytics] The authors evaluated the effects of chimeric Ab27 using cancer cells expressing endogenous transmembrane 4 L six family member 5 (TM4SF5) or stably overexpressing TM4SF5 in vivo and in vitro.

[Molecular Biology Reports] Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway