xenograft models

[Nature Communications] Investigators developed a B cell-activating factor (BAFF) ligand-based CAR and generated BAFF CAR-T cells using a non-viral gene delivery method.

[Proceedings of the National Academy of Sciences of the United States of America] The authors engineered the highly migratory and brain tumor tropic human neural stem cells LM008 to continuously secrete high amounts of functional, stable, full-length antibodies against human epidermal growth factor receptor 2 (HER2) without compromising the stemness of LM008 cells.

[npj Precision Oncology] Complementary functional analyses of polyclonal EGFR-mutant cell pools showed a dose-dependent enrichment of BRAFV600E and a loss of EGFR inhibitor susceptibility.

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

[Molecular Cancer therapeutics] Investigators tested the activity of co-targeting of estrogen receptor, HER2, and cyclin-dependent kinases 4/6 therapy with tucatinib, palbociclib, and fulvestrant in HR+/HER2+ human breast tumor cell lines and xenograft models.

[Nature Communications] Scientists generated a comprehensive prostate cancer transcriptome atlas that described the roadmap to tumor progression in a qualitative and quantitative manner. Using patient-derived xenograft models, they functionally validated their observations and add single-cell resolution.